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35380-71-3

35380-71-3 structure
35380-71-3 structure
  • Name: ESTRADIOL HEMIHYDRATE
  • Chemical Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol,hydrate
  • CAS Number: 35380-71-3
  • Molecular Formula: C18H26O3
  • Molecular Weight: 562.779
  • Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
  • Create Date: 2018-06-11 17:11:24
  • Modify Date: 2024-01-02 17:36:56
  • Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].
Name (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol,hydrate
Synonyms (17β)-Estra-1,3,5(10)-triene-3,17-diol hydrate (2:1)
ESTRADIOL HEMIHYDRATE
cxy7b3q98z
Estra-1,3,5(10)-triene-3,17-diol, (17β)-, hydrate (2:1)
Estra-1,3,5(10)-triene-3,17β-diol hydrate (2:1)
unii-cxy7b3q98z
Description Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].
Related Catalog
In Vitro Estradiol hemihydrate (10 nM, 7 days) induces neural differentiation and increased neurite branching of human endometrial stem cells (hEnSCs)[1]. Estradiol hemihydrate (17β-estradiol, 10 nM, 7 days) increases the expression of neuron-like cell markers (Tuj-1, nestin and NF-H) in neural-like cells differentiated from hEnSCs[1]. Cell Differentiation Assay[1] Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration: 10 nM Incubation Time: 7 days Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively. Immunofluorescence[1] Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration: 10 nM Incubation Time: 7 days Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.
In Vivo Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1]. Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1]. Animal Model: FBN-ARO-KO Mice[2] Dosage: 1 nM Administration: Treated for the hippocampal slices Result: Rescued long-term potentiation (LTP) amplitude of both male and female mice. Animal Model: FBN-ARO-KO Mice[2] Dosage: 0.0167 mg Administration: Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation. Result: Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects.
References

[1]. Elham Hasanzadeh. Defining the role of 17β-estradiol in human endometrial stem cells differentiation into neuron-like cells. Cell Biol Int. 2021 Jan;45(1):140-153.

[2]. Yujiao Lu, et al. Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory. J Neurosci. 2019 Apr 10;39(15):2792-2809.

Boiling Point 445.9ºC at 760mmHg
Molecular Formula C18H26O3
Molecular Weight 562.779
Flash Point 209.6ºC
Exact Mass 562.365845
PSA 49.69000
LogP 3.54490
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H351-H360Fd-H362
Precautionary Statements P201-P263-P281-P308 + P313
Personal Protective Equipment Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T
Risk Phrases 60-63-40-64
Safety Phrases 53-36/37-45
RIDADR NONH for all modes of transport

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