39156-67-7

39156-67-7 structure

Name: Dihydrocytochalasin B
Chemical Name: dihydrocytochalasin b
CAS Number: 39156-67-7
Molecular Formula: C₂₉H₃₉NO₅
Molecular Weight: 481.62400
Catalog: Signaling Pathways Cytoskeleton Arp2/3 Complex
Create Date: 2018-08-26 20:41:11
Modify Date: 2024-01-06 15:15:43
Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis, causes cell rounding and a loss of actin microfilament bundles[2]. Dihydrocytochalasin B is related to transcytoplasmic movement of calcium by inhibiting active calcium transport and causes a Ca+increase in the mucosal scrapings[3].

Name	dihydrocytochalasin b
Synonyms	2,3-Dihydro-cytochalasin B 21,22-dihydro-phomin EINECS 254-324-4 21,22-Dihydrocytochalalsin B CYTOCHALASIN B,DIHYDRO 21,22-dihydro-cytochalasin-B dihydrocytocholasin-B 7(S),20(R)-dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione DHCB (7S,13E,16R,20R)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione MFCD00010541

Description	Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis, causes cell rounding and a loss of actin microfilament bundles[2]. Dihydrocytochalasin B is related to transcytoplasmic movement of calcium by inhibiting active calcium transport and causes a Ca+increase in the mucosal scrapings[3].
Related Catalog	Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex Research Areas >> Others
References	[1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70. [2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51. [3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62.

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300-H310-H330-H351
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+,T
Risk Phrases	26/27/28-40
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
Hazard Class	6.1(a)