2457-80-9
2457-80-9 structure
- Name: Adenylthiomethylpentose
- Chemical Name: 5'-S-methyl-5'-thioadenosine
- CAS Number: 2457-80-9
- Molecular Formula: C11H15N5O3S
- Molecular Weight: 297.333
- Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
- Create Date: 2018-03-28 08:00:00
- Modify Date: 2024-01-05 21:28:34
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5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
| Name | 5'-S-methyl-5'-thioadenosine |
|---|---|
| Synonyms |
5-Methylthioadenosine
1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-Ribofuranose β-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio- Vitamin L2 5'-S-Methylthioadenosine (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol 5'-S-Methyl-5'-thioadenosine 7-[Tetrahydro-3,4-dihydroxy-5-(methylmeracptomrthyl)-2-futyl]adenine Adenosine, 5'-S-methyl-5'-thio- 5'-Deoxy-5'-(methylthio)adenosine MFCD00010533 MTA,Methylthioadenosine 5'-Deoxy-5'-Methylthioadenosine Adenylthiomethylpentose (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol |
| Description | 5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | 5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration[1]. |
| References |
[1]. Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.7±65.0 °C at 760 mmHg |
| Melting Point | 210-213ºC (dec.) |
| Molecular Formula | C11H15N5O3S |
| Molecular Weight | 297.333 |
| Flash Point | 342.5±34.3 °C |
| Exact Mass | 297.089569 |
| PSA | 144.61000 |
| LogP | 0.67 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.843 |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU7410000 |
| HS Code | 2934999090 |
| Precursor 10 | Previous 1/3 Next |
|---|---|
| DownStream 4 | |
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |