Name | N,N′-Dimethylthiourea |
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Synonyms |
Thiourea, N,N'-dimethyl-
N,N'-DIMETHYLTHIOUREA 1,3-dimethyl-2-thiourea N,N‘-Dimethylthiourea 1,3-Dimethylthiourea MFCD00004923 N,N′-dimethylthiourea EINECS 208-588-2 |
Description | N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2]. |
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Related Catalog | |
In Vivo | N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks[1]. |
References |
[2]. Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS. |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 121.6±23.0 °C at 760 mmHg |
Melting Point | 61-63 °C |
Molecular Formula | C3H8N2S |
Molecular Weight | 104.174 |
Flash Point | 27.3±22.6 °C |
Exact Mass | 104.040817 |
PSA | 56.15000 |
LogP | -0.35 |
Vapour Pressure | 14.5±0.2 mmHg at 25°C |
Index of Refraction | 1.516 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301-H317 |
Precautionary Statements | P280-P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | R25;R43 |
Safety Phrases | S36/37-S45 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | YT1520000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2930909090 |
Precursor 10 | |
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DownStream 10 | |
HS Code | 2930909090 |
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Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |