14110-64-6

14110-64-6 structure

Name: Cytochalasin A
Chemical Name: cytochalasin a
CAS Number: 14110-64-6
Molecular Formula: C₂₉H₃₅NO₅
Molecular Weight: 477.592
Catalog: Biochemical Plant extracts
Create Date: 2018-10-03 17:10:35
Modify Date: 2024-01-05 22:11:21
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2].

Name	cytochalasin a
Synonyms	cytochalasin a from helminthosporium dematioideum (3E,11Z)-16-Benzyl-13-hydroxy-9,15-diméthyl-14-méthylène-6,7,8,9,10,12a,13,14,15,15a,16,17-dodécahydro-2H-oxacyclotétradécino[2,3-d]isoindole-2,5,18-trione MFCD00005935 20-dehydro-phomin 2H-Oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,11Z)- (3E,11Z)-16-Benzyl-13-hydroxy-9,15-dimethyl-14-methylene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione 7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,20,23-trione CytochalasinA from Drechslera dematioidea Cytochalasin A (3E,11Z)-16-benzyl-13-hydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione Dehydrophomin EINECS 237-964-9 Cytochalasin dreschslera dematioidea (3E,11Z)-16-Benzyl-13-hydroxy-9,15-dimethyl-14-methylen-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindol-2,5,18-trion 5,5-Didehydrophomin

Description	Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	HIV-1 protease[1]
References	[1]. Kerman K, et al. An electrochemical approach for the detection of HIV-1 protease. Chem Commun (Camb). 2007 Oct 7;(37):3829-31. [2]. Antonio Bottalico, et al. Cytochalasins: Structure-activity relationships. Phytochemistry Volume 29, Issue 1, 1990.

Density	1.2±0.1 g/cm3
Boiling Point	725.1±60.0 °C at 760 mmHg
Melting Point	147 to 148'ºC
Molecular Formula	C₂₉H₃₅NO₅
Molecular Weight	477.592
Flash Point	392.3±32.9 °C
Exact Mass	477.251526
PSA	92.70000
LogP	2.83
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.590
Storage condition	−20°C
Water Solubility	ethanol: 20 mg/mL, clear, colorless \| Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300-H310-H330-H361
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;T: Toxic;
Risk Phrases	R26/27/28
Safety Phrases	28-36/37-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
Packaging Group	I
Hazard Class	6.1(a)
HS Code	29349990

64760-39-0

14110-64-6

Literature: Journal of the American Chemical Society, , vol. 99, # 20 p. 6756 - 6758

14930-96-2

14110-64-6

Literature: Helvetica chimica acta, , vol. 53, # 4 p. 696 - 724

14903-09-4

14110-64-6

Literature: Journal of the American Chemical Society, , vol. 99, # 20 p. 6756 - 6758

Precursor 2
14930-96-2 14903-09-4
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