Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Methotrexate
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methotrexate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

91431-42-4

91431-42-4 structure

91431-42-4 structure

Name: Methotrexate
Chemical Name: (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate
CAS Number: 91431-42-4
Molecular Formula: C₁₆H₁₅ClO₆
Molecular Weight: 338.74000
Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
Create Date: 2018-06-22 14:29:07
Modify Date: 2024-01-19 21:18:25
RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor.

Name	(4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate
Synonyms	6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene LONAPALENE Lonapaleno Lonapalenum 6-chloro-2,3-dimethoxy-1,4-naphthalenediol 1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene 6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene Methotrexate RS4317

Description	RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Inflammation/Immunology
Target	5-lipoxygenase[1]
In Vitro	RS4317 (Lonapalene) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1].
References	[1]. Black AK, et al. Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4.

Density	1.309g/cm3
Boiling Point	424.9ºC at 760mmHg
Molecular Formula	C₁₆H₁₅ClO₆
Molecular Weight	338.74000
Flash Point	159.3ºC
Exact Mass	338.05600
PSA	71.06000
LogP	3.36100
Index of Refraction	1.571

106-39-8 structure

106-39-8

~%

91431-42-4 structure

91431-42-4

Literature: Moore, Harold W.; Perri, Steven T. Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 996 - 1003

56961-92-3 structure

56961-92-3

~%

91431-42-4 structure

91431-42-4

Literature: Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511

106-51-4 structure

106-51-4

~%

91431-42-4 structure

91431-42-4

Literature: Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511

3117-02-0 structure

3117-02-0

~%

91431-42-4 structure

91431-42-4

Literature: Flynn; Nies Tetrahedron Letters, 1986 , vol. 27, # 42 p. 5075 - 5078

110104-16-0 structure

110104-16-0

~%

91431-42-4 structure

91431-42-4

Literature: Flynn; Nies Tetrahedron Letters, 1986 , vol. 27, # 42 p. 5075 - 5078

Precursor 5
106-39-8 56961-92-3 106-51-4 3117-02-0
110104-16-0
DownStream 0

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