91431-42-4

91431-42-4 structure

Name	(4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate
Synonyms	RS-43197 LONAPALENE 6-chloro-2,3-dimethoxy-1,4-naphthalenediol 6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene Lonapalene Lonapalene (RS4317) RS4317 Lopalene 1,4-Naphthalenediol, 6-chloro-2,3-dimethoxy-, 1,4-diacetate 1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene RS4317 (Lonapalene) 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene Lonapaleno Lonapalenum

Description	RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Inflammation/Immunology
Target	5-lipoxygenase[1]
In Vitro	RS4317 (Lonapalene) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1].
References	[1]. Black AK, et al. Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4.

106-39-8

91431-42-4

Literature: Moore, Harold W.; Perri, Steven T. Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 996 - 1003

56961-92-3

91431-42-4

106-51-4

91431-42-4

3117-02-0

91431-42-4

Literature: Flynn; Nies Tetrahedron Letters, 1986 , vol. 27, # 42 p. 5075 - 5078

110104-16-0

91431-42-4

Literature: Flynn; Nies Tetrahedron Letters, 1986 , vol. 27, # 42 p. 5075 - 5078