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  • DC Chemicals Limited
  • China
  • Product Name: Indisulam
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


165668-41-7

165668-41-7 structure
165668-41-7 structure
  • Name: Indisulam
  • Chemical Name: 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • CAS Number: 165668-41-7
  • Molecular Formula: C14H12ClN3O4S2
  • Molecular Weight: 385.846
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
  • Create Date: 2018-12-20 20:18:29
  • Modify Date: 2024-01-11 13:13:24
  • Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2].

Name 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
Synonyms E7070
Indisulam (IND)
1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-
indisulam
N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
N-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
Indisulam (USAN/INN)
1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl)
Description Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2].
Related Catalog
Target

Carbonic anhydrase[1].

References

[1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82.

[2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.

Density 1.7±0.1 g/cm3
Boiling Point 668.9±65.0 °C at 760 mmHg
Molecular Formula C14H12ClN3O4S2
Molecular Weight 385.846
Flash Point 358.4±34.3 °C
Exact Mass 384.995789
PSA 138.88000
LogP 2.08
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.731
Storage condition 2-8℃
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport
HS Code 2935009090
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%