Indisulam

Modify Date: 2026-07-13 13:20:47

Indisulam structure	Common Name	Indisulam
	CAS Number	165668-41-7	Molecular Weight	385.846
	Density	1.7±0.1 g/cm3	Boiling Point	668.9±65.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂ClN₃O₄S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	358.4±34.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Indisulam

Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2].

Name	4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
Synonym	More Synonyms

Description	Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	Carbonic anhydrase[1].
References	[1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82. [2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.

Density	1.7±0.1 g/cm3
Boiling Point	668.9±65.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₂ClN₃O₄S₂
Molecular Weight	385.846
Flash Point	358.4±34.3 °C
Exact Mass	384.995789
PSA	138.88000
LogP	2.08
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.731
InChIKey	SETFNECMODOHTO-UHFFFAOYSA-N
SMILES	NS(=O)(=O)c1ccc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)cc1
Storage condition	2-8℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Name: Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method
Source: ChEMBL
Target: Carbonic anhydrase 9
External Id: CHEMBL830080

Name: Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2...
Source: ChEMBL
Target: Carbonic anhydrase 12
External Id: CHEMBL1246743

Name: Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 ...
Source: ChEMBL
Target: Carbonic anhydrase 9
External Id: CHEMBL1246742

Name: Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay
Source: ChEMBL
Target: Carbonic anhydrase 2
External Id: CHEMBL1246741

Name: Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay
Source: ChEMBL
Target: Carbonic anhydrase 1
External Id: CHEMBL1246740

Name: Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration metho...
Source: ChEMBL
Target: Carbonic anhydrase 1
External Id: CHEMBL830213

Name: Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method
Source: ChEMBL
Target: Carbonic anhydrase 2
External Id: CHEMBL830081

Name: Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kineti...
Source: ChEMBL
Target: Carbonic anhydrase 3
External Id: CHEMBL898699

Name: Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15...
Source: ChEMBL
Target: Carbonic anhydrase 12
External Id: CHEMBL1167309

Name: Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 ...
Source: ChEMBL
Target: Carbonic anhydrase 9
External Id: CHEMBL1167308

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E7070

Indisulam (IND)

indisulam

N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

N-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide

Indisulam (USAN/INN)

1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl)

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Indisulam
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: INDISULAM
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.