141699-55-0

141699-55-0 structure

Name: 1-N-Boc-3-hydroxyazetidine
Chemical Name: 1-Boc-3-hydroxyazetidine
CAS Number: 141699-55-0
Molecular Formula: C₈H₁₅NO₃
Molecular Weight: 173.210
Catalog: Organic raw materials Hydrocarbon compounds and their derivatives Cyclic hydrocarbon
Create Date: 2018-07-04 09:56:40
Modify Date: 2026-07-01 22:34:06
1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

Name	1-Boc-3-hydroxyazetidine
Synonyms	1-TERT-BUTOXYCBONYL-3-HYDROXYAZETIDINE MFCD04115305 1-(TERT-BUTOXYCBONYL)-3-HYDROXYAZETIDINE 1-TERT-BUTOXYCBONYL-3-AZETIDINOL 1-Boc-azetidin-3-ol N-Boc-3-Azetidinol 1-BOC-3-Hydroxyazetidine 1-N-Boc-3-hydroxyazetidine ISO 9001：2015 REACH 1-Azetidinecboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester 3-HYDROXYAZETIDINE, N-BOC PROTECTED TERT-BUTYL 3-HYDROXYAZETIDINE-1-CBOXYLATE 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine tert-butyl 3-hydro×yazetidine-1-cbo×ylate 1-Boc-3-(Hydroxy)azetidine tert-Butyl 3-hydroxyazetidine-1-cboxylate, 1-(tert-Butoxycbonyl)-3-hydroxyazetidine 1-(tert-Butoxycbonyl)-3-hydroxyazetidine > cbamate Q092 RSM2) 1-Boc-3-hydroxyazetidine tert-Butyl 3-Hydroxyazetidine-1-cboxylate 3-Hydroxyazetidine-1-cboxylic Acid tert-Butyl Ester 3-HYDROXY-AZETIDINE-1-CBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-3-hydroxyl-azetidine BUTTPK 75 N-BOC-3-HYDROXYAZETIDINE J-141699 1-tert-Butoxycbonyl-3-azetidinol tert-butyl 3-hydroxyazetidine-1-cboxylate 1-BOC-3-(HYDROXY)AZETIDINE 1-(tert-Butoxycbonyl)-3-azetidinol Bicitinib-012 N-Boc-3-hydroxyazetidine 1-azetidinecboxylic acid, 3-hydroxy-, 1,1-dimethylethyl 3-hydroxy-1-azetidinecboxylic acid tert-butyl ester 1-N-BOC-3-HYDROXYAZETIDINE tert-butyl-3-hydroxyazetidine-4-cboxylate tert-Butyl 3-Hydroxyazetidine-1-carboxylate 3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester N-Boc-Azetidin-3-ol

Description	1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi,Xn
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%