Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2R,4S)-1-TERT-BUTYL 2-METHYL 4-HYDROXYPYRROLIDINE-1,2-DICARBOXYLATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

135042-17-0

135042-17-0 structure

Name: Boc-trans-D-Hyp-OMe
Chemical Name: (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
CAS Number: 135042-17-0
Molecular Formula: C₁₁H₁₉NO₅
Molecular Weight: 245.272
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2019-01-09 12:50:43
Modify Date: 2026-07-05 17:52:39
Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Name	(2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
Synonyms	N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER //BP (Tert-Butoxy)carbonyl D-trans-Hyp-OMe N-Boc-trans-D-Hyp-Ome Methyl (2R,4S)-1-Boc-4-hydroxypyrrolidine-2-cboxylate trans-Boc-D-Hpy-Ome 1,2-Pyrrolidinedicboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S) 1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicboxylate 1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-hydroxy-1,2-pyrrolidinedicboxylate (4S)-4-Hydroxy-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicboxylate N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER (CAS NO.135-0) (2R,4S)-4-hydroxypyrrolidine-1,2-dicboxylate (2R,4S)-4-Hydroxypyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester 2-Methyl ester (N-Boc-trans-4-Hydroxy-D-proline Methyl ester N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER 1-(tert-Butyl) 2-methyl (2R,4S)-4-hydroxy-1,2-pyrrolidinedicboxylate N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este N-Boc-Trans-5-Hydroxy-D-Proline Methyl Ester N-tert-butoxycbonyl-trans-4-hydroxy-D-proline Methyl ester (2R,4S)-4-Hydroxypyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester 2-methyl 1-tert-butyl 2-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicboxylate Boc-trans-4-Hydroxy-D-proline Methyl ester (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicboxylate/N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER Boc-D-trans-Hyp-OMe 1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate (2R,4S)-4-Hydroxypyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester 2-methyl ester (2R,4S)-N-Boc-trans-4-hydroxy-D-proline methyl ester Methyl (4S)-1-Boc-4-hydroxy-D-prolinate (2R,4S)-N-Boc-4-hydroxyproline methyl ester

Description	Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.3±0.1 g/cm3
Boiling Point	387.6±42.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₉NO₅
Molecular Weight	245.272
Flash Point	188.2±27.9 °C
Exact Mass	245.126328
PSA	76.07000
LogP	-0.17
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.520
Storage condition	2-8°C

Hazard Codes	Xi

Precursor 0
DownStream 5
84520-67-2 142347-81-7 256487-77-1 1123307-53-8
77450-03-4

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1396855-86-9	1421477-69-1
1885-87-6	2197410-76-5
1340852-21-2	1706451-36-6
1447965-88-9	1448073-65-1
1354000-50-2	2203716-25-8