142347-81-7
142347-81-7 structure
- Name: tans-4-Hydroxy-D-proline hydrochloride
- Chemical Name: trans-4-Hydroxy-D-proline hydrochloride
- CAS Number: 142347-81-7
- Molecular Formula: C5H10ClNO3
- Molecular Weight: 167.591
- Catalog: Biochemical Amino acids and their derivatives Proline derivatives
- Create Date: 2018-12-31 18:02:16
- Modify Date: 2026-07-04 18:02:11
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tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
| Name | trans-4-Hydroxy-D-proline hydrochloride |
|---|---|
| Synonyms |
rans-4-Hydroxy-D-prolinehydrochloride
Trans-Hydroxy-D-Proline HCl salt (2R,4S)-4-hydroxypyrrolidine-2-cboxylic acid Hydrochloride/trans-4-Hydroxy-D-proline hydrochloride (2R,4S)-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID HCL (4S)-4-Hydroxy-D-proline hydrochloride (1:1) (4S)-4-Hydroxy-D-proline HCl tans-4-Hydroxy-D-proline (hydrochloride) HCl.trans-D-Hyp-OH trans-D-Hpy-OH.HCl D-Proline, 1-hydroxy-, hydrochloride (1:1) D-trans-4-Hydroxyproline Hydrochloride trans-4-Hydroxy-D-proline Hydrochloride (4S)-4-Hydroxy-D-proline Hydrochloride NSC 206273 Hydrochloride trans-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride (2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride (2R,4S)-trans-4-hydroxy-D-proline hydrochloride rel-(2R,4S)-4-Hydroxypyrrolidine-2-cboxylic acid hydrochloride trans-4-Hydroxypyrrolidine-2-cboxylic acid hydrochloride 4-(S)-Hydroxypyrrolidine-2-(R)-cboxylic Acid Hydrochloride (4S)-4-hydroxy-D-Proline hydrochloride (1:1) trans-4-Hydroxy-D-proline HCl trans-4-Hydroxy-D-proline acid hydrochloride 4-hydroxy-2-pyrrolidinecboxylic acid hydrochloride (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride D-Proline, 4-hydroxy-, (4S)-, hydrochloride (1:1) D-Hydroxyproline Hydrochloride D-Proline, 4-hydroxy-,hydrochloride, trans (2R,4S)-4-Hydroxypyrrolidine-2-cboxylic acid hydrochloride (2R,4S)-(+)-4-Hydroxy-D-proline Hydrochloride 1-Hydroxy-D-proline hydrochloride (1:1) TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE //BP D-Proline, 4-hydroxy-, hydrochloride (1:1), (4S) |
| Description | tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Boiling Point | 368.6ºC at 760mmHg |
|---|---|
| Molecular Formula | C5H10ClNO3 |
| Molecular Weight | 167.591 |
| Flash Point | 176.7ºC |
| Exact Mass | 167.034927 |
| PSA | 69.56000 |
| Vapour Pressure | 6.22E-07mmHg at 25°C |
| Hazard Codes | Xi |
|---|
|
~69%
142347-81-7 |
| Literature: Pandey, Anil K.; Naduthambi, Devan; Thomas, Krista M.; Zondlo, Neal J. Journal of the American Chemical Society, 2013 , vol. 135, # 11 p. 4333 - 4363 |
| Precursor 1 | |
|---|---|
| DownStream 2 | |
