- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: tans-4-Hydroxy-D-proline hydrochloride
- Price: ￥2248.0/10g ￥1348.0/5g ￥448.0/1g
- Purity: 95.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: tans-4-Hydroxy-D-proline hydrochloride
- Price: ￥Inquiry/500g
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: tans-4-Hydroxy-D-proline hydrochloride
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: TRANS-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
142347-81-7
142347-81-7 structure
- Name: tans-4-Hydroxy-D-proline hydrochloride
- Chemical Name: trans-4-Hydroxy-D-proline hydrochloride
- CAS Number: 142347-81-7
- Molecular Formula: C5H10ClNO3
- Molecular Weight: 167.591
- Catalog: Biochemical Amino acids and their derivatives Proline derivatives
- Create Date: 2018-12-31 18:02:16
- Modify Date: 2024-01-17 18:17:40
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tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
| Name | trans-4-Hydroxy-D-proline hydrochloride |
|---|---|
| Synonyms |
(2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
D-Proline, 1-hydroxy-, hydrochloride (1:1) trans-4-Hydroxy-D-proline Hydrochloride 1-Hydroxy-D-proline hydrochloride (1:1) (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride trans-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride (4S)-4-Hydroxy-D-proline hydrochloride (1:1) D-Proline, 4-hydroxy-, (4S)-, hydrochloride (1:1) |
| Description | tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Boiling Point | 368.6ºC at 760mmHg |
|---|---|
| Molecular Formula | C5H10ClNO3 |
| Molecular Weight | 167.591 |
| Flash Point | 176.7ºC |
| Exact Mass | 167.034927 |
| PSA | 69.56000 |
| Vapour Pressure | 6.22E-07mmHg at 25°C |
| Hazard Codes | Xi |
|---|
|
~69%
142347-81-7 |
| Literature: Pandey, Anil K.; Naduthambi, Devan; Thomas, Krista M.; Zondlo, Neal J. Journal of the American Chemical Society, 2013 , vol. 135, # 11 p. 4333 - 4363 |
| Precursor 1 | |
|---|---|
| DownStream 2 | |
