Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Lubiprostone
Price: ￥1058.0/5mg ￥1128.0/10mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Lubiprostone
Price: $450.0/100mg $850.0/250mg $1700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Lubiprostone
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Lubiprostone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

136790-76-6

136790-76-6 structure

Name: Lubiprostone
Chemical Name: Lubiprostone
CAS Number: 136790-76-6
Molecular Formula: C₂₀H₃₂F₂O₅
Molecular Weight: 390.462
Catalog: Biochemical Inhibitor Transmembrane Transporters CFTR activator
Create Date: 2018-07-11 09:05:37
Modify Date: 2024-01-02 18:12:45
Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation.Target: OthersLubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). From Wikipedia.

Name	Lubiprostone
Synonyms	Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11α,15R)- 13,14-dihydro-15-keto-16,16-difluoro-Prostaglandin E1 9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID 13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard DK-PGD2 (3aR,4R,5R,6aS)-4-[(1E)-4,4-Difluoro-3-oxo-1-octen-1-yl]-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl 4-biphenylcarboxylate 13,14-dihydro-15-keto-prostaglandin D2 [1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E)-4,4-difluoro-3-oxo-1-octen-1-yl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester 13,14-Dihydro-15-keto-PGD2 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid 13,14-Dihydro-15-ketoprostadlandin D2 Lubiprostone (11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid 13,14-dihydro-15-keto PD2 13,14-dihydro-15-keto-16,16-difluoro-PGE1

Description	Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation.Target: OthersLubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). From Wikipedia.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Metabolic Disease
References	[1]. http://en.wikipedia.org/wiki/Lubiprostone

Density	1.2±0.1 g/cm3
Boiling Point	532.3±50.0 °C at 760 mmHg
Melting Point	56-59ºC
Molecular Formula	C₂₀H₃₂F₂O₅
Molecular Weight	390.462
Flash Point	275.7±30.1 °C
Exact Mass	390.221771
PSA	83.83000
LogP	2.85
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.486
Storage condition	-20°C Freezer

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	UK8257750
HS Code	2918990090

1236109-40-2

~70%

136790-76-6

Literature: APOTEX PHARMACHEM INC.; KOTHAKONDA, Kiran, Kumar; WANG, Fan; GUNTOORI, Bhaskar, Reddy; NGUYEN, Minh, T.N.; CECCARELLI, Alfredo, Paul; ZHAO, Yajun; KOTIPALLI, Uma; DUNCAN, Sammy, Chris; MILNEE, Kaarina, K.; KELLS, Kevin, W.; MONTEMAYOR, Laura, Kaye Patent: WO2010/83597 A1, 2010 ; Location in patent: Page/Page column 54-55 ;

1236109-29-7

136790-76-6

Literature: WO2011/91513 A1, ; Page/Page column 13-14 ;