136790-76-6
136790-76-6 structure
- Name: Lubiprostone
- Chemical Name: Lubiprostone
- CAS Number: 136790-76-6
- Molecular Formula: C20H32F2O5
- Molecular Weight: 390.462
- Catalog: Biochemical Inhibitor Transmembrane Transporters CFTR activator
- Create Date: 2018-07-11 09:05:37
- Modify Date: 2026-07-09 20:23:54
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Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation.Target: OthersLubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). From Wikipedia.
| Name | Lubiprostone |
|---|---|
| Synonyms |
Ru 0211
lubiprostone Lubiprostone CAS 13,14-Dihydro-15-keto-PGD2 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid TIANFU-CHEM - Lubiprostone Rubiprostone Prostan-1-oicacid,16,16-difluoro-11-hydroxy-9,15-dioxo-, (11α) Lubiprostone (SPI-0211 13,14-dihydro-15-keto-16,16-difluoro-PGE1 7-[(1r,4r,6r,9r)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo[4.3.0]non-9-yl]htanoic acid (11α)-16,16-Difluoro-11-hydroxy-9,15-dioxoprostan-1-oic acid Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11α) 13,14-dihydro-15-keto-16,16-difluoro-Prostaglandin E1 C13707 SPI 0211;UNII-7662KG2R6K;AMITIZA LUBIPROSTONE 9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID 16,16-Difluoro-11alpha-hydroxy-9,15-dioxoprostan-1-oic Acid 13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard DK-PGD2 (3aR,4R,5R,6aS)-4-[(1E)-4,4-Difluoro-3-oxo-1-octen-1-yl]-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl 4-biphenylcarboxylate 13,14-dihydro-15-keto-prostaglandin D2 [1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E)-4,4-difluoro-3-oxo-1-octen-1-yl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester Lubiprostone, >= Lubiprostone //BP Lubiprostone API Rubyprostone Lubiprostone (ring open) 13,14-Dihydro-15-ketoprostadlandin D2 LubiprostoneQ: What is Lubiprostone Q: What is the CAS Number of Lubiprostone Q: What is the storage condition of Lubiprostone Q: What e the applications of Lubiprostone (11α)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid (11a)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid (11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid 13,14-dihydro-15-keto PD2 Lubiprostone, 10 mM in DMSO Lubipristone |
| Description | Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation.Target: OthersLubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). From Wikipedia. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 532.3±50.0 °C at 760 mmHg |
| Melting Point | 56-59ºC |
| Molecular Formula | C20H32F2O5 |
| Molecular Weight | 390.462 |
| Flash Point | 275.7±30.1 °C |
| Exact Mass | 390.221771 |
| PSA | 83.83000 |
| LogP | 2.85 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.486 |
| Storage condition | -20°C Freezer |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| RTECS | UK8257750 |
| HS Code | 2918990090 |
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| Literature: APOTEX PHARMACHEM INC.; KOTHAKONDA, Kiran, Kumar; WANG, Fan; GUNTOORI, Bhaskar, Reddy; NGUYEN, Minh, T.N.; CECCARELLI, Alfredo, Paul; ZHAO, Yajun; KOTIPALLI, Uma; DUNCAN, Sammy, Chris; MILNEE, Kaarina, K.; KELLS, Kevin, W.; MONTEMAYOR, Laura, Kaye Patent: WO2010/83597 A1, 2010 ; Location in patent: Page/Page column 54-55 ; |
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| Precursor 3 | |
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| DownStream 1 | |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |