67200-34-4

67200-34-4 structure

Name: Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one
Chemical Name: smer3
CAS Number: 67200-34-4
Molecular Formula: C₁₁H₄N₄O₂
Molecular Weight: 224.175
Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
Create Date: 2018-11-26 10:26:39
Modify Date: 2024-01-08 07:15:19
SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30[1].

Name	smer3
Synonyms	Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one, 5-Oxoindeno<1,2-e>furazano<3,4-b>pyrazin Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one 9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one 2-Oxa-1,3,4,10-tetraaza-cyclopenta[b]fluoren-9-one

Description	SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
In Vitro	In yeast cells, Met4 ubiquitination is blocked in cells exposed to SMER3 (0-60 μM). The met4Δ cells are less susceptible to growth inhibition by SMER3[1]. Addition of SMER3 to the ligase reactions inhibited ubiquitination of Met4 by SCFMet30 in a dose-dependent manner. SMER3 significantly inhibits the binding of Met30 to Skp1, and does not affect the Skp1 and Met30 protein levels[1].
References	[1]. Mariam Aghajan, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol. 2010 Jul;28(7):738-42.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

485-47-2

17220-38-1

~59%

67200-34-4

938-24-9

67200-34-4

Literature: Pirogov; Mel'nikova; Tselinskii Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 12 p. 1473 - 1474

Precursor 3
485-47-2 17220-38-1 938-24-9
DownStream 0