Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one
Modify Date: 2025-08-26 15:58:24
![Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one Structure](https://image.chemsrc.com/caspic/176/67200-34-4.png)
Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one structure
|
Common Name | Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one | ||
|---|---|---|---|---|
| CAS Number | 67200-34-4 | Molecular Weight | 224.175 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 437.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C11H4N4O2 | Melting Point | 296 °C(dec.) | |
| MSDS | Chinese USA | Flash Point | 218.2±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Indeno[1,2-b]furazano[3,4-E]pyrazin-9-oneSMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30[1]. |
| Name | smer3 |
|---|---|
| Synonym | More Synonyms |
| Description | SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30[1]. |
|---|---|
| Related Catalog | |
| In Vitro | In yeast cells, Met4 ubiquitination is blocked in cells exposed to SMER3 (0-60 μM). The met4Δ cells are less susceptible to growth inhibition by SMER3[1]. Addition of SMER3 to the ligase reactions inhibited ubiquitination of Met4 by SCFMet30 in a dose-dependent manner. SMER3 significantly inhibits the binding of Met30 to Skp1, and does not affect the Skp1 and Met30 protein levels[1]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.2±55.0 °C at 760 mmHg |
| Melting Point | 296 °C(dec.) |
| Molecular Formula | C11H4N4O2 |
| Molecular Weight | 224.175 |
| Flash Point | 218.2±31.5 °C |
| Exact Mass | 224.033432 |
| PSA | 81.77000 |
| LogP | 0.90 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.779 |
| InChIKey | SFSSAKVWCKFRHE-UHFFFAOYSA-N |
| SMILES | O=C1c2ccccc2-c2nc3nonc3nc21 |
|
~59%
Indeno[1,2-b]fu... CAS#:67200-34-4 |
| Literature: Ignat'ev, Nikolai V.; Schulte, Michael; Koppe, Karsten; Barthen, Peter; Zlotin, Sergei G.; Makhova, Nina N.; Sheremetev, Aleksei B.; Valente, Anabela A. Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 5 p. 1205 - 1216 |
|
~%
Indeno[1,2-b]fu... CAS#:67200-34-4 |
| Literature: Pirogov; Mel'nikova; Tselinskii Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 12 p. 1473 - 1474 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
|
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.
Nat. Biotechnol. 28 , 738 - 742, (2010) The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pat... |
| Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one, |
| 5-Oxoindeno<1,2-e>furazano<3,4-b>pyrazin |
| Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one |
| 9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one |
| 2-Oxa-1,3,4,10-tetraaza-cyclopenta[b]fluoren-9-one |