291533-11-4

291533-11-4 structure

Name: PG 116800
Chemical Name: 2-[[4-[(4-methoxybenzoyl)amino]phenyl]sulfonylamino]-5-morpholin-4-ylpent-3-ynoic acid
CAS Number: 291533-11-4
Molecular Formula: C₂₄H₂₇N₃O₇S
Molecular Weight: 501.55200
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2016-09-28 17:19:49
Modify Date: 2024-09-03 12:19:04
PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research[1].

Name	2-[[4-[(4-methoxybenzoyl)amino]phenyl]sulfonylamino]-5-morpholin-4-ylpent-3-ynoic acid

Description	PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
References	[1]. Piotr Krzeski, et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007;9(5):R109.