DC Chemicals Limited
China
Product Name: Jedi2
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

651005-90-2

651005-90-2 structure

651005-90-2 structure

Name: Jedi2
Chemical Name: 2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid
CAS Number: 651005-90-2
Molecular Formula: C₁₀H₈O₃S
Molecular Weight: 208.23400
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-02-02 09:25:45
Modify Date: 2024-01-03 06:28:28
Jedi2 is a Piezo1 channel activator, but no specific Piezo2 activators. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770 μM[1].

Name	2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid
Synonyms	hms1431a19

Description	Jedi2 is a Piezo1 channel activator, but no specific Piezo2 activators. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770 μM[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Jedi2 evokes Piezo1-mediated Ca2+ influx. Jedi2 (200 μM) specifically elicits dose-dependent responses in mPiezo1-transfected cells, but not in mPiezo2- or vector-transfected cells [1]. Jedi2 (1 mM) causes an increase in Ca2+ in mCherry-positive HEK293T cells transfected with the mPiezo1-mCherry construct, which also responded to Yoda1 (30 μM) [1].
References	[1]. Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300.

Molecular Formula	C₁₀H₈O₃S
Molecular Weight	208.23400
Exact Mass	208.01900
PSA	78.68000
LogP	3.01470

Hazard Codes	Xn