110429-36-2

110429-36-2 structure

Name: N-Methylparoxetine
Chemical Name: N-Methyl Paroxetine
CAS Number: 110429-36-2
Molecular Formula: C₂₀H₂₂FNO₃
Molecular Weight: 343.392
Create Date: 2018-07-14 15:57:25
Modify Date: 2024-01-02 16:24:20
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes. It inhibits serotonin (5-HT) uptake in rat brain synaptosomes and has been used as a precursor in the synthesis of paroxetine.

Name	N-Methyl Paroxetine
Synonyms	Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methyl- Paroxetine Related Compound F 3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methyl-, (3S,4R)- (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)-1-methylpiperidine MFCD03788781 N-Methyl Paroxetine (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine Paroxetine Impurity 9

Density	1.2±0.1 g/cm3
Boiling Point	443.7±45.0 °C at 760 mmHg
Melting Point	111 °C
Molecular Formula	C₂₀H₂₂FNO₃
Molecular Weight	343.392
Flash Point	222.1±28.7 °C
Exact Mass	343.158386
PSA	30.93000
LogP	3.91
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.562
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

533-31-3

317323-77-6

~78%

110429-36-2

Literature: Segura, Mireia; Roura, Lidia; De La Torre, Rafael; Joglar, Jesus Bioorganic Chemistry, 2003 , vol. 31, # 3 p. 248 - 258

110429-35-1

74-88-4

~92%

110429-36-2

Literature: Wei, Peng; Kaatz, Glenn W.; Kerns, Robert J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3093 - 3097

105812-81-5

110429-36-2

Literature: Bioorganic Chemistry, , vol. 31, # 3 p. 248 - 258

459-57-4

110429-36-2

Literature: Synthetic Communications, , vol. 42, # 22 p. 3344 - 3360

533-31-3

1258537-32-4

110429-36-2

Literature: EP1286965 B1, ; Page 5 ;