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968-81-0

968-81-0 structure
968-81-0 structure

Name acetohexamide
Synonyms Metaglucina
Gamadiabet
1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea
MFCD00072156
acetoxehamide
Acetohexamidum
Hypoglicil
Dimelin
Acetohexamid
N(2)-Cyclohexyl-N(1)-(4-acetylbenzenesulfonyl) Urea
EINECS 213-530-4
N'-<4-Acetyl-benzolsulfonyl>-N-cyclohexyl-harnstoff
N-(p-Acetyl-benzolsulfonyl)-N'-(cyclohexyl)-harnstoff
Dymelor
Dimelor
Acetohexamida
N-Cyclohexyl-N'-<4-acetyl-benzolsulfonyl>-harnstoff
Description Acetohexamide is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2; stimulate the pancreas to secrete insulin.
Related Catalog
Density 1.3g/cm3
Melting Point 188-190° (GB 912789); mp 175-177° (Marshall)
Molecular Formula C15H20N2O4S
Molecular Weight 324.39500
Exact Mass 324.11400
PSA 100.72000
LogP 4.07240
Appearance solid | white
Index of Refraction 1.581
Water Solubility DMSO: ~45 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YR7350000
CHEMICAL NAME :
Urea, 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-
CAS REGISTRY NUMBER :
968-81-0
LAST UPDATED :
199806
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C15-H20-N2-O4-S
MOLECULAR WEIGHT :
324.43
WISWESSER LINE NOTATION :
L6TJ AMVMSWR DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,34,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,18,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
900 mg/kg
SEX/DURATION :
female 26-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,187,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83998 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 627 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83998 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1626 (estimated) No. of Female Employees: 833 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS YR7350000
HS Code 2935009090
Precursor  0

DownStream  1

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%