15763-11-8

15763-11-8 structure
15763-11-8 structure
  • Name: 2-Hydrazinyl-adenosine
  • Chemical Name: 2-Hydrazino Adenosine
  • CAS Number: 15763-11-8
  • Molecular Formula: C10H15N7O4
  • Molecular Weight: 297.27
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
  • Create Date: 2017-03-02 12:21:49
  • Modify Date: 2024-01-19 15:08:40
  • 2-Hydrazinyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name 2-Hydrazino Adenosine
Synonyms (2R,3R,4S,5R)-2-(6-amino-2-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Description 2-Hydrazinyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 2.29±0.1 g/cm3(Predicted)
Boiling Point 583.1±60.0 °C(Predicted)
Melting Point 208-210ºC
Molecular Formula C10H15N7O4
Molecular Weight 297.27
Exact Mass 297.11900
PSA 177.59000
Index of Refraction 2.002
Storage condition 2-8°C
Hazard Codes Xn

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Literature: RELIABLE BIOPHARMACEUTICAL CORPORATION; WOOLDRIDGE, Luzviminda, T.; MA, Chun; NADJI, Sourena Patent: WO2012/149196 A1, 2012 ; Location in patent: Page/Page column 17 ;

~82%

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Literature: CV THERAPEUTICS, INC. Patent: WO2008/143667 A1, 2008 ; Location in patent: Page/Page column 20-21 ; WO 2008/143667 A1

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Literature: Van Tilburg, Erica W.; Von Frijtag Drabbe Kuenzel, Jacobien; De Groote, Miriam; IJzerman, Ad P. Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 420 - 429

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Literature: Niiya; Olsson; Thompson; Silvia; Ueeda Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4557 - 4561

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Literature: Schaeffer; Thomas Journal of the American Chemical Society, 1958 , vol. 80, p. 3738,3741

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Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

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Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

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Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

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15763-11-8 structure

15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447