53179-11-6
53179-11-6 structure
- Name: Loperamide
- Chemical Name: loperamide
- CAS Number: 53179-11-6
- Molecular Formula: C29H33ClN2O2
- Molecular Weight: 477.04
- Catalog: API Digestive system medication Laxative antidiarrheal
- Create Date: 2018-02-23 08:00:00
- Modify Date: 2026-06-30 11:37:05
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Loperamide (ADL 2-1294) is a selective μ opioid receptor agonist with Kis of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide can be used as an antidiarrheal agent[1].
| Name | loperamide |
|---|---|
| Synonyms |
4-[4-Chlorophenyl]-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutanamide
4-(4-chlorophenyl)-n,n-dimethyl-alpha Loperamida 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N DIMETHYL-A,A DIPHENYL-1-PEIPERIDINE BUTANAMIDEHCL Loperamide Monomer Loperamide 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl- 2,2-diphenylbutanamide C07080 [3H]-Loperamide Ioperamide 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-2,2-diphenyl-N,N-dimethylbutyramide Loperacap 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide Apo-Loperamide MFCD00600388 EINECS 258-416-5 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide Loperamide //BP 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide 4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb Maalox Anti-Diarrheal 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-di(phenyl)butanamide 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide Kaopectate II utanamide LOPERAMIDE Imodium 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide Tebloc Loperamidum 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide LoperamideQ: What is Loperamide Q: What is the CAS Number of Loperamide Q: What is the storage condition of Loperamide 4-[4-Hydroxy-4-(4-chlorophenyl)-1-piperidinyl]-2,2-diphenyl-N,N-dimethylbutanamide Nu-Loperamide |
| Description | Loperamide (ADL 2-1294) is a selective μ opioid receptor agonist with Kis of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide can be used as an antidiarrheal agent[1]. |
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| Related Catalog | |
| Target |
Ki: 3 nM (μ opioid receptor), 48 nM (δ opioid receptor), 1156 nM (κ opioid receptor)[1] |
| References |
| Density | 1.187g/cm3 |
|---|---|
| Boiling Point | 647.2ºC at 760 mmHg |
| Molecular Formula | C29H33ClN2O2 |
| Molecular Weight | 477.04 |
| Flash Point | 345.2ºC |
| Exact Mass | 476.22300 |
| PSA | 43.78000 |
| LogP | 5.02590 |
| Index of Refraction | 1.6 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | C,Xi |
|---|---|
| Risk Phrases | R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin . R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . |
| Safety Phrases | S26-S36/37/39-S45-S37/39 |
| RIDADR | UN 2735 8/PG 3 |
| WGK Germany | 3 |
| RTECS | FF2200000 |
| HS Code | 29252000 |
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53179-11-6 |
| Literature: Chen, Zhengming; Davies, Ellen; Miller, Wendy S.; Shan, Shen; Valenzano, Kenneth J.; Kyle, Donald J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5275 - 5279 |
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53179-11-6 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5275 - 5279 |
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53179-11-6 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5275 - 5279 |
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53179-11-6 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| HS Code | 29252000 |
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