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- Dayang Chem (Hangzhou) Co., Ltd.
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- Product Name: 2,4-Diamino-6-hydroxypyrimidine
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- Henan Tianfu Chemical Co., Ltd.
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- Product Name: 2,4-Diamino-6-hydroxypyrimidine,56-06-4
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- Zhongshan Xingrui Chemical Co. , Ltd.
- China
- Product Name: 2,4-Diamino-6-hydroxypyrimidine
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56-06-4
56-06-4 structure
- Name: 2,4-Diamino-6-hydroxypyrimidine
- Chemical Name: 2,4-Diamino-6-hydroxypyrimidine
- CAS Number: 56-06-4
- Molecular Formula: C4H6N4O
- Molecular Weight: 126.12
- Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Hydroxypyrimidine
- Create Date: 2018-05-29 08:00:00
- Modify Date: 2026-06-30 13:37:17
-
2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].
| Name | 2,4-Diamino-6-hydroxypyrimidine |
|---|---|
| Synonyms |
2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol
2,6-Diaminopyrimidin-4-one 2,4-Diamino-6-hydroxypyrimidine ISO 9001：2015 REACH Pemetrexed Impurity 16 NSC-18522 2,6-DIAMINO-4-HYDROXYPYRIMIDINE 2,6-DIAMINO-4(1H)-PYRIMIDINONE 2,4-DIAMINO-6(1H)-PYRIMIDINONE 2,4-DIAMINO-6-PYRIMIDINOL 1-4 2,4-DIAMINO-6-HYDROXYPYRIDIMIDINE TIMTEC-BB SBB004252 2,6-DIAMINO-3H-PYRIMIDIN-4-ONE 2,4-Diamino-6. -Hydroxypyimidine 2,4-Diamino-6-hydroxypyrimidiine 4(1H)-Pyrimidinone, 2,6-diamino 2,4-Diamino-6-hydroxypyrimidine > 2,6-Diamino-4(3H)-pyrimidinone 2,4-Diamino-6-hydroxy 4-DiaMino-6-hydroxypyriMidine NSC18522 2,6-Diamino-4(1H)-pyrimidinone AURORA KA-376 InChI=1/C4H6N4O/c-/h1H,(H5,5,6,7,8,9 2,4-diaminohypoxanthine 4(1H)-Pyrimidinone, 2,6-diamino- (8CI,9CI) 2,4-DIAMINO-6-HYDROXY PYRIMIDINE 2,6-Diamino-1H-pyrimidin-4-on 2,6-DIAMINO-4-PYRIMIDINOL 6-Hydroxy-2,4-pyrimidinediamine Minoxidil Impurity 19 Venadapib Impurity 45 2,4-DiaMino-6-hydroxypyriMidine 2,6-Diaminopyrimidin-4(1H)-one 6-Hydroxy-2,4-diaminopyrimidine DIAMINO6HYDROXY PYRIMID 2,6-DIAMINOPYRIMIDIN-4-OL 6-Aminoisocytosine DAHP 3-methylidene-1,5-benzodioxine 4(3H)-pyrimidinone, 2,6-diamino 2,6-diaminopyrimidin-4(3H)-one 2,6-Diamino-3,4-dihydropyrimidine-4-one 2,6-diaminopyrimidin-4-ol 2,4-Diamino-6-hydroxypyrimidine,2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone 2,6-diamino-4-hydroxy-pyrimidine 6-hydroxy-2,4-diaminopyrimidine 2,6-Diamino-4-Hydroxyprimidine MFCD00006098 2,4-Diamino-6-pyrimidinone EINECS 200-254-4 2,6-DIAMINO-4-PYRIMIDINONE 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone 2,6-diamino-1H-pyrimidin-4-one 2,4- two-6- aMinohydroxy pyriMidine 2,4-DIAMINOPYRIMIDIN-6-OL |
| Description | 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. |
|---|---|
| Related Catalog | |
| Target |
GTP cyclohydrolase I[1] |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 524.0±53.0 °C at 760 mmHg |
| Melting Point | 285-286 °C (dec.)(lit.) |
| Molecular Formula | C4H6N4O |
| Molecular Weight | 126.12 |
| Flash Point | 270.7±30.9 °C |
| Exact Mass | 126.054161 |
| PSA | 98.05000 |
| LogP | -1.29 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.770 |
| Storage condition | Desiccate at +4°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29335995 |
|
~%
56-06-4 |
| Literature: Popova; Studentsov Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 435 - 438 |
|
~%
56-06-4 |
| Literature: Terashima, Isamu; Kohda, Kohfuku Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 503 - 508 |
| Precursor 3 | |
|---|---|
| DownStream 10 | |
![2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine structure](https://image.chemsrc.com/caspic/303/7355-55-7.png)
![2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile structure](https://image.chemsrc.com/caspic/270/69205-79-4.png)
![4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester structure](https://image.chemsrc.com/caspic/176/155405-80-4.png)
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |