2,4-Diamino-6-hydroxypyrimidine

Modify Date: 2026-06-30 13:37:17

2,4-Diamino-6-hydroxypyrimidine Structure
2,4-Diamino-6-hydroxypyrimidine structure
 Common Name 2,4-Diamino-6-hydroxypyrimidine
CAS Number 56-06-4 Molecular Weight 126.12
Density 1.6±0.1 g/cm3 Boiling Point 524.0±53.0 °C at 760 mmHg
Molecular Formula C4H6N4O Melting Point 285-286 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 270.7±30.9 °C

 Use of 2,4-Diamino-6-hydroxypyrimidine


2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].

Summary: 2,4-Diamino-6-hydroxypyrimidine (CAS号：56-06-4)，molecular formula C4H6N4O，molecular weight 126.12，appears as slightly white crystals，melting point 285-286 °C，boiling point 524.0±53.0 °C，density 1.6±0.1 g/cm3. For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2,4-Diamino-6-hydroxypyrimidine
Synonym More Synonyms

 2,4-Diamino-6-hydroxypyrimidine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].
Related Catalog
Target

GTP cyclohydrolase I[1]

References

[1]. Sung YJ, et al. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16(2):101-8.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.6±0.1 g/cm3
Boiling Point 524.0±53.0 °C at 760 mmHg
Melting Point 285-286 °C (dec.)(lit.)
Molecular Formula C4H6N4O
Molecular Weight 126.12
Flash Point 270.7±30.9 °C
Exact Mass 126.054161
PSA 98.05000
LogP -1.29
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.770
Storage condition Desiccate at +4°C

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29335995

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

2,4-DIAMINO-6-FLUOROPYRIMIDINE structure

2,4-DIAMINO-6-F...

CAS#:696-83-3

~%

2,4-Diamino-6-hydroxypyrimidine Structure

2,4-Diamino-6-h...

CAS#:56-06-4

Learn More
Literature: Popova; Studentsov Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 435 - 438
Thiophenol structure

Thiophenol

CAS#:108-98-5

2,6-Diamino-4-(benzyloxy)pyrimidine structure

2,6-Diamino-4-(...

CAS#:100061-59-4

~%

Benzyl(phenyl)sulfane structure

Benzyl(phenyl)s...

CAS#:831-91-4

2,4-Diamino-6-hydroxypyrimidine Structure

2,4-Diamino-6-h...

CAS#:56-06-4

Learn More
Literature: Terashima, Isamu; Kohda, Kohfuku Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 503 - 508

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles26

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

GTP cyclohydrolase I: purification, characterization, and effects of inhibition on nitric oxide synthase in nocardia species.

Appl. Environ. Microbiol. 69(12) , 7507-7513, (2003)

GTP cyclohydrolase I (GTPCH) catalyzes the first step in pteridine biosynthesis in Nocardia sp. strain NRRL 5646. This enzyme is important in the biosynthesis of tetrahydrobiopterin (BH4), a reducing ...

Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.

Hypertension 52(3) , 484-90, (2008)

GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial NO synthase (eNOS) dictating, at least partly, the ba...

Attenuation of biopterin synthesis prevents Escherichia coli K1 invasion of brain endothelial cells and the development of meningitis in newborn mice.

J. Infect. Dis. 207(1) , 61-71, (2013)

Elevated levels of pterins and nitric oxide (NO) are observed in patients with septic shock and bacterial meningitis. We demonstrate that Escherichia coli K1 infection of human brain microvascular end...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2,6-diaminopyrimidin-4(3H)-one
2,6-Diaminopyrimidin-4-one
2,4-Diamino-6-hydroxypyrimidine
2,6-diaminopyrimidin-4-ol
2,4-Diamino-6-hydroxy
2,6-diamino-4-hydroxy-pyrimidine
6-hydroxy-2,4-diaminopyrimidine
2,6-Diamino-4(1H)-pyrimidinone
AURORA KA-376
MFCD00006098
2,4-Diamino-6-pyrimidinone
2,6-Diaminopyrimidin-4(1H)-one
EINECS 200-254-4
2,4-diaminohypoxanthine
6-Aminoisocytosine
6-Hydroxy-2,4-pyrimidinediamine
DAHP
2,4-DIAMINO-6-HYDROXY PYRIMIDINE

 2,4-Diamino-6-hydroxypyrimidine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of 2,4-Diamino-6-hydroxypyrimidine?
A: Polar surface area (PSA) of 2,4-Diamino-6-hydroxypyrimidine is 98.05000.
Q: What are the storage conditions for 2,4-Diamino-6-hydroxypyrimidine?
A: Storage conditions for 2,4-Diamino-6-hydroxypyrimidine: Desiccate at +4°C.
Q: What is the melting point of 2,4-Diamino-6-hydroxypyrimidine?
A: Melting point of 2,4-Diamino-6-hydroxypyrimidine is 285-286 °C (dec.)(lit.).
Q: What is the LogP of 2,4-Diamino-6-hydroxypyrimidine?
A: LogP of 2,4-Diamino-6-hydroxypyrimidine is -1.29.
Q: What are the uses of 2,4-Diamino-6-hydroxypyrimidine?
A: Main uses of 2,4-Diamino-6-hydroxypyrimidine: 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].
Q: What is the molecular weight of 2,4-Diamino-6-hydroxypyrimidine?
A: Molecular weight of 2,4-Diamino-6-hydroxypyrimidine is 126.12.
Q: What are the upstream materials of 2,4-Diamino-6-hydroxypyrimidine?
A: Related upstream materials(CAS) of 2,4-Diamino-6-hydroxypyrimidine: 108-98-5;100061-59-4;696-83-3.
Q: What are the downstream products of 2,4-Diamino-6-hydroxypyrimidine?
A: Related downstream products(CAS) of 2,4-Diamino-6-hydroxypyrimidine: 3764-01-0;7355-55-7;69205-79-4;116436-03-4;3054-70-4;137205-94-8;137205-95-9;2387-48-6;155405-80-4;156-83-2.
Q: What is the English name of 2,4-Diamino-6-hydroxypyrimidine?
A: The English name of 2,4-Diamino-6-hydroxypyrimidine is 2,4-Diamino-6-hydroxypyrimidine.
Q: What is the CAS number of 2,4-Diamino-6-hydroxypyrimidine?
A: CAS number of 2,4-Diamino-6-hydroxypyrimidine is 56-06-4.

 2,4-Diamino-6-hydroxypyrimidinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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