2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine structure
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Common Name | 2,4-Diamino-6-hydroxypyrimidine | ||
|---|---|---|---|---|
| CAS Number | 56-06-4 | Molecular Weight | 126.12 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 524.0±53.0 °C at 760 mmHg | |
| Molecular Formula | C4H6N4O | Melting Point | 285-286 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 270.7±30.9 °C | |
Use of 2,4-Diamino-6-hydroxypyrimidine2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. |
| Name | 2,4-Diamino-6-hydroxypyrimidine |
|---|---|
| Synonym | More Synonyms |
| Description | 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. |
|---|---|
| Related Catalog | |
| Target |
GTP cyclohydrolase I[1] |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 524.0±53.0 °C at 760 mmHg |
| Melting Point | 285-286 °C (dec.)(lit.) |
| Molecular Formula | C4H6N4O |
| Molecular Weight | 126.12 |
| Flash Point | 270.7±30.9 °C |
| Exact Mass | 126.054161 |
| PSA | 98.05000 |
| LogP | -1.29 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.770 |
| Storage condition | Desiccate at +4°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29335995 |
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2,4-Diamino-6-h... CAS#:56-06-4 |
| Literature: Popova; Studentsov Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 435 - 438 |
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2,4-Diamino-6-h... CAS#:56-06-4 |
| Literature: Terashima, Isamu; Kohda, Kohfuku Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 503 - 508 |
| Precursor 3 | |
|---|---|
| DownStream 10 | |
CAS#:3764-01-0![2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine structure](https://image.chemsrc.com/caspic/303/7355-55-7.png)
CAS#:7355-55-7![2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile structure](https://image.chemsrc.com/caspic/270/69205-79-4.png)
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CAS#:2387-48-6![4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester structure](https://image.chemsrc.com/caspic/176/155405-80-4.png)
CAS#:155405-80-4
CAS#:156-83-2| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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GTP cyclohydrolase I: purification, characterization, and effects of inhibition on nitric oxide synthase in nocardia species.
Appl. Environ. Microbiol. 69(12) , 7507-7513, (2003) GTP cyclohydrolase I (GTPCH) catalyzes the first step in pteridine biosynthesis in Nocardia sp. strain NRRL 5646. This enzyme is important in the biosynthesis of tetrahydrobiopterin (BH4), a reducing ... |
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Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
Hypertension 52(3) , 484-90, (2008) GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial NO synthase (eNOS) dictating, at least partly, the ba... |
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Attenuation of biopterin synthesis prevents Escherichia coli K1 invasion of brain endothelial cells and the development of meningitis in newborn mice.
J. Infect. Dis. 207(1) , 61-71, (2013) Elevated levels of pterins and nitric oxide (NO) are observed in patients with septic shock and bacterial meningitis. We demonstrate that Escherichia coli K1 infection of human brain microvascular end... |
| 2,6-diaminopyrimidin-4(3H)-one |
| 2,6-Diaminopyrimidin-4-one |
| 2,4-Diamino-6-hydroxypyrimidine |
| 2,6-diaminopyrimidin-4-ol |
| 4-Pyrimidinol, 2,6-diamino- |
| 2,4-Diamino-6-hydroxy |
| 2,6-diamino-4-hydroxy-pyrimidine |
| 6-hydroxy-2,4-diaminopyrimidine |
| 2,6-Diamino-4(1H)-pyrimidinone |
| AURORA KA-376 |
| MFCD00006098 |
| 2,4-Diamino-6-pyrimidinone |
| 2,6-Diaminopyrimidin-4(1H)-one |
| EINECS 200-254-4 |
| 2,4-diaminohypoxanthine |
| 6-Aminoisocytosine |
| 6-Hydroxy-2,4-pyrimidinediamine |
| DAHP |
| 2,4-DIAMINO-6-HYDROXY PYRIMIDINE |
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