212631-61-3
212631-61-3 structure
- Name: PD 198306
- Chemical Name: N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-(4-iodo-2-methylanilino)benzamide
- CAS Number: 212631-61-3
- Molecular Formula: C18H16F3IN2O2
- Molecular Weight: 476.23200
- Catalog: Signaling Pathways MAPK/ERK Pathway MEK
- Create Date: 2017-01-31 03:54:32
- Modify Date: 2024-01-12 18:13:52
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PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects[1].
| Name | N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-(4-iodo-2-methylanilino)benzamide |
|---|---|
| Synonyms |
hms3269f09
hms3229h15 PD 198306 |
| Description | PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects[1]. |
|---|---|
| Related Catalog | |
| Target |
MEK |
| In Vitro | PD198306 significantly inhibits Tha-GFP replication by 25% at 10 μM, after 36 h[2]. PD198306 (5 μM) reduces Tha-Crimson replication significantly by 20% at 18 h but such a result could not be confirmed at 36 h[2]. Cell Cycle Analysis[2] Cell Line: Human induced pluripotent stem cells (iPSC) Concentration: 10 μM Incubation Time: 6 hours Result: Inhibited Tha-Crimson replication at 10 μM, reducing it by 30% at 18 h and 50% at 36 h. |
| In Vivo | Intrathecal administration of PD 198306 (1-30 μg per 10 μL) dose-dependently (1-30 μg) blocks static allodynia in both the streptozocin and the chronic constriction injury (CCI) models of neuropathic pain[1]. Animal Model: Male Sprague Dawley rats (250-300 g) bearing neuropathic pain[1] Dosage: 1-30 μg per 10 μL and 3 mg per 100 μL (PD 198306 is suspended in cremophor:ethanol:water, 1 : 1 : 8.) Administration: Single doses of intrathecal (i.t.) or intraplantar (ipl) of PD 198306 (1-30 μg per 10 μL and 3 mg per 100 μL respectively Result: Intrathecal administration dose-dependently (1-30 μg) blocked static allodynia the streptozocin model of neuropathic pain. The minimum effective doses (MED) of 3 μg significantly blocked static allodynia 30 min after treatment. Both 10 μg and the highest dose used (30 μg) totally blocked the maintenance of static allodynia, for up to 1 h. |
| References |
| Density | 1.686g/cm3 |
|---|---|
| Molecular Formula | C18H16F3IN2O2 |
| Molecular Weight | 476.23200 |
| Exact Mass | 476.02100 |
| PSA | 50.36000 |
| LogP | 5.29580 |
| Index of Refraction | 1.631 |