249537-73-3

249537-73-3 structure

Name: NFAT Inhibitor trifluoroacetate salt
Chemical Name: NFAT Inhibitor
CAS Number: 249537-73-3
Molecular Formula: C₇₅H₁₂₀N₂₀O₂₂S
Molecular Weight: 1685.94
Catalog: Peptides
Create Date: 2016-10-02 01:30:29
Modify Date: 2025-08-22 05:04:31
NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu;MAGPHPVIVITGPHEE.

Name	NFAT Inhibitor
Synonyms	L-Methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-L-glutamic acid h-met-ala-gly-pro-his-pro-val-ile-val-ile-thr-gly-pro-his-glu-glu-oh L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl- met-ala-gly-pro-his-pro-val-ile-val-ile-thr-gly-pro-his-glu-glu magphpvivitgphee

Description	NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu;MAGPHPVIVITGPHEE.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Peptides
In Vitro	NFAT Inhibitor (VIVIT peptide) is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. NFAT Inhibitor (100 μM) that effectively inhibits NFAT1-calcineurin binding and NFAT1 dephosphorylation, does not inhibit calcineurin phosphatase activity toward the RII phosphopeptide. NFAT Inhibitor selectively inhibits NFAT activation without disrupting other calcineurin-dependent pathways[1]. NFAT Inhibitor attenuates NFAT-dependant protein expression in immune cells. NFAT activity regulates proinflammatory secretion and is attenuated by NFAT Inhibitor in murine microglia cultures[2].
References	[1]. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33. [2]. Nagamoto-Combs K, et al. Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells). J Neurosci. 2010 Jul 14;30(28):9641-6.

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