NFAT Inhibitor trifluoroacetate salt

Modify Date: 2024-01-03 17:08:19

NFAT Inhibitor trifluoroacetate salt structure	Common Name	NFAT Inhibitor trifluoroacetate salt
	CAS Number	249537-73-3	Molecular Weight	1685.94
	Density	1.3±0.1 g/cm3	Boiling Point	1982.4±65.0 °C at 760 mmHg
	Molecular Formula	C₇₅H₁₂₀N₂₀O₂₂S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	1152.7±34.3 °C

Use of NFAT Inhibitor trifluoroacetate salt

NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu;MAGPHPVIVITGPHEE.

Name	NFAT Inhibitor
Synonym	More Synonyms

Description	NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu;MAGPHPVIVITGPHEE.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Peptides
In Vitro	NFAT Inhibitor (VIVIT peptide) is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. NFAT Inhibitor (100 μM) that effectively inhibits NFAT1-calcineurin binding and NFAT1 dephosphorylation, does not inhibit calcineurin phosphatase activity toward the RII phosphopeptide. NFAT Inhibitor selectively inhibits NFAT activation without disrupting other calcineurin-dependent pathways[1]. NFAT Inhibitor attenuates NFAT-dependant protein expression in immune cells. NFAT activity regulates proinflammatory secretion and is attenuated by NFAT Inhibitor in murine microglia cultures[2].
References	[1]. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33. [2]. Nagamoto-Combs K, et al. Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells). J Neurosci. 2010 Jul 14;30(28):9641-6.

Density	1.3±0.1 g/cm3
Boiling Point	1982.4±65.0 °C at 760 mmHg
Molecular Formula	C₇₅H₁₂₀N₂₀O₂₂S
Molecular Weight	1685.94
Flash Point	1152.7±34.3 °C
PSA	650.94000
LogP	-0.76
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.580
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

L-Methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-L-glutamic acid

h-met-ala-gly-pro-his-pro-val-ile-val-ile-thr-gly-pro-his-glu-glu-oh

L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-

met-ala-gly-pro-his-pro-val-ile-val-ile-thr-gly-pro-his-glu-glu

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