264622-58-4

264622-58-4 structure

Name: MRS 1754
Chemical Name: N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
CAS Number: 264622-58-4
Molecular Formula: C₂₆H₂₆N₆O₄
Molecular Weight: 486.52200
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-12-27 12:36:05
Modify Date: 2024-01-08 07:34:18
MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1].

Name	N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Synonyms	MRS 1754 hydrate MRS 1754 ML 9 hydrochloride Lopac-M-6316

Description	MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A2B Adenosine Receptor[1]
In Vitro	The most potent displacer of [3H]MRS 1754 binding is MRS 1754. The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM[1].
References	[1]. Ji X, et al. [³H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 Mar 15;61(6):657-63.

Safety Phrases	22-24/25