Shanghai Nianxing Industrial Co., Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phorbol 12,13-dibutyrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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37558-16-0

37558-16-0 structure

37558-16-0 structure

Name: Phorbol-12
Chemical Name: phorbol 12,13-dibutanoate
CAS Number: 37558-16-0
Molecular Formula: C₂₈H₄₀O₈
Molecular Weight: 504.61200
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2018-06-19 10:00:06
Modify Date: 2026-07-04 14:50:00
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].

Name	phorbol 12,13-dibutanoate
Synonyms	C03634 Phorbol 12,13-Dibutyrate (1-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-5-oxo-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulene-4aα,7bα,9β,9aα-tetrol 9,9a-dibutyrate 13-dibutyrate PDBU 9β,9aα-Bis(butyryloxy)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one (1,1bS,4,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutyrate Butanoic acid, (1,1bS,4,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester lester,(1-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-al (1-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5-oxo-5H-cyclopropa[3,4]benz[1,2-e]azulene-9β,9aα-diol 9,9a-dibutyrate MFCD00036783 Phorbol 12 Phorbol 12,13-dibutyrate,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester hyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diy butanoicacid,1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymet Phorbol-12,13-dibutyrate - - Calbiochem PHORBOL 12,13-DIBUTYRATE, 4BETA PHORBOL 12,13-DIBUTYRATE,4BETA Phorbol 12,13dibutyrate,Phorbol 12,13 dibutyrate Phorbol 12,13-dibutanoate (1,1bS,4,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester Phorbol 12,13-dibutyrate

Description	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKC[1]
In Vitro	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (1 MM) activates PKC and inhibited Na/K-ATPase transport activity in OK cells[3].
References	[1]. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25. [2]. Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62. [3]. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.

Density	1.27g/cm3
Boiling Point	623.4ºC at 760mmHg
Molecular Formula	C₂₈H₄₀O₈
Molecular Weight	504.61200
Flash Point	199.3ºC
Exact Mass	504.27200
PSA	130.36000
LogP	2.63210
Appearance	powder \| clear, light yellow, film
Index of Refraction	1.574
Storage condition	−20°C
Water Solubility	H2O: 30 μM

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S26-S36
RIDADR	2928
WGK Germany	3
RTECS	EK7767000
Packaging Group	II
Hazard Class	6.1(a)

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