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Product Name: SGT-151(CUMYL-PEGACLONE)
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1099-87-2

1099-87-2 structure

Name: Dehydroepiandrosterone sulfate sodium salt
Chemical Name: Sodium prasterone sulfate
CAS Number: 1099-87-2
Molecular Formula: C₁₉H₂₇NaO₅S
Molecular Weight: 390.469
Catalog: API Hormone and endocrine-regulating drugs Androgen and anabolic hormone drugs
Create Date: 2018-08-29 15:39:38
Modify Date: 2026-07-12 17:31:45
Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone[1].

Name	Sodium prasterone sulfate
Synonyms	CUMYL-PEGACLONE(SGT-151) 3-(sulfooxy)-,sodiumsalt,(3-beta)-androst-5-en-17-on Androst-5-en-17-one, 3b-hydroxy-, hydrogen sulfate, sodium salt (6CI, 7CI, 8CI) sodiumandrost-5-en-17-one-3-beta-ylsulfate (3b)-3-(Sulfooxy)androst-5-en-17-one Sodium Salt Dehydroiandrosterone sulfate sodium salt hydrate (DHEA sulfate sodium hydrate) Sulfuric acid sodium 17-oxoandrosta-5-ene-3β-yl ester salt EINECS 214-152-2 DHEA sulfate,sodiuM salt Prasterone sulfate sodium DEHYDROISOANDROSTERONE 3-SULFATE, SODIUM SALT HYDRATE PRASTERONE SODIUM SULFATE SODIUM DEHYDROIANDROSTERONE SULFATE HYDRATE 3b-Hydroxy-5-androsten-17-one Sodium Sulfate sodium dehydroiandrosterone-3-sulfate sodium dehydroisoandrosterone-3-sulfate Natrium-(3β)-androst-5-en-17-on-3-sulfat DEHYDROISOANDROSTERONE SULFATE SODIUM 5-ANDROSTEN-3-BETA-OL-17-ONE SULPHATE, SODIUM SALT sodiumprasteronesulfate DEHYDROIANDROSTERONE SULFATE SODIUM 5-ANDROSTEN-3BETA-OL-17-ONE-3-SULFATE SODIUM dha-s Androst-5-en-17-one, 3-(sulfooxy)-, sodium salt, (3b)- (9CI) sodiumdehydroiandrosteronesulfate Androst-5-en-17-one, 3.beta.-hydroxy-, hydrogen sulfate, sodium salt PRASTERONE SULFATE SODIUM SALT 3b-Hydroxyandrost-5-en-17-one Hydrogen Sulfate Sodium Salt prasterone sodium sulphate Mylis Dehydroiandrosterone 3-sulfate sodium Sodium dehydroepiandrosterone sulfate SODIUM PRASTERONE SULFATE CAS NO.:1-2 DEHYDROIANDROSTERONE 3-SULFATE SODIUM SALT 3β-Hydroxyandrost-5-en-17-one sulfatesodium salt SODIUM PRASTERONR SULFATE Sodium prasterone sulfate //BP prasterone sulfate sodium salt sodium (3beta)-androst-5-en-17-one 3-sulphate 3β-(Sodiosulfooxy)androst-5-en-17-one 3-beta-hydroxy-androst-5-en-17-onesterwithsodiumsulfate mylis Prasterone Sulfate, Sodium salt(DHEA Sulfate, Sodium salt) 3β-[(Sodiooxysulfonyl)oxy]androsta-5-ene-17-one 5-ANDROSTEN-3BETA-OL-17-ONE SULFATE SODIUM SALT DEHYDROIANDROSTERONE-3-SULFATE SODIUM SALT HYDRATE DEHYDROIANDROSTERONE SODIUM SULFATE Dehydroiandrosterone-3-sulfate Sodium Salt Sodium Dehydroisoandrosterone-3-sulfate Dehydroiandrosterone-[13C3] Sulfate Sodium Salt in Methanol Dehydroiandrosterone Sulfate Sodium Salt in Methanol DEHYDROIANDROSTERONE SODIUM SULPHATE Sodium Prasterone Sulfate (1.0mg/ml in Acetonitrile) DEHYDROISOANDROSTERONE 3-SULFATE SODIUM SALT Teloin Androst-5-en-17-one, 3-(sulfooxy)-, sodium salt, (3β)- (1:1) androst-5-en-17-one,3-beta-hydroxy-,sulfate(ester),sodiumsalt Sodium (3β)-17-oxoandrost-5-en-3-yl sulfate Dehydroiandrosterone (Dhea) -0 / Sodium Sodium dehydroepiandrosterone-3-sulfate MFCD00010470 SGT-151(CUMYL-PEGACLONE) sodiumdehydroepiandrosteronesulfate SODIUM DEHYDROISOANDROSTERONE-3-SULFATE HYDRATE SODIUM DEHYDROIANDROSTERONE-3-SULFATE HYDRATE Dehydroepiandrosterone sulfate sodium Astenile DEHYDROIANDROSTERONE SULFATE SODIUM SALT Androst-5-en-17-one, 3-(sulfooxy)-, sodium salt, (3.beta.) Dehydroiandrosterone 3-sulfate (DHEAS) sodium salt solution Dehydroepiandrosterone-3-sulfate sodium salt

Description	Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Jens Neunzig, et al. Dehydroepiandrosterone Sulfate (DHEAS) Stimulates the First Step in the Biosynthesis of Steroid Hormones. PLoS One. 2014 Feb 21;9(2):e89727.

Melting Point	148-149 °C (dec.)(lit.)
Molecular Formula	C₁₉H₂₇NaO₅S
Molecular Weight	390.469
Exact Mass	390.147675
PSA	91.88000
LogP	4.44450
Index of Refraction	10 ° (C=4, MeOH)
Storage condition	?20°C
Water Solubility	methanol: clear to hazy

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8397400

CHEMICAL NAME :: Androst-5-en-17-one, 3-beta-hydroxy-, ester with sodium sulfate

CAS REGISTRY NUMBER :: 1099-87-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C19-H27-O5-S.Na

MOLECULAR WEIGHT :: 390.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: JMGZAI Japan Medical Gazette. (Tokyo, Japan) V.1-18(?), 1964-81. Discontinued. Volume(issue)/page/year: 18(5),10,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,687,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 523 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,1852,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1005 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,1852,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 468 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,1852,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 48,189,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,687,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,1852,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 899 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,1852,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 274 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,1852,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 48,189,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg/30D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,1857,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5460 mg/kg/26W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,3016,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg/32D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,2989,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18200 mg/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in other cell count (unspecified)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 10,3001,1976 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 500 mg/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,201,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,201,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,201,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 7-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,201,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3 gm/kg

SEX/DURATION :: female 7-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - sex ratio

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,201,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 7-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,201,1976

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F,C
Risk Phrases	R11
Safety Phrases	16-26-36/37/39-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	BV8397400
Flash Point(F)	48.2 °F
Flash Point(C)	9 °C

53-43-0

1099-87-2

Literature: Chemistry and Biodiversity, , vol. 10, # 12 p. 2197 - 2208

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53-43-0
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53-43-0

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