496794-70-8

496794-70-8 structure

Name: HhAntag
Chemical Name: N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
CAS Number: 496794-70-8
Molecular Formula: C₂₄H₂₃ClN₄O₃
Molecular Weight: 450.91700
Catalog: Signaling Pathways Stem Cell/Wnt Gli
Create Date: 2018-12-24 15:32:09
Modify Date: 2025-08-21 12:56:07
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.IC50 value:Target: Gli

Name	N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
Synonyms	CS-1233 GLI1-mediated tranion inhibitor HhAntag

Description	HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.IC50 value:Target: Gli
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Gli Research Areas >> Cancer
References	[1]. Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30. [2]. Mahindroo, Neeraj; Connelly, Michele C.; Punchihewa, Chandanamali; et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorganic & Medicinal Chemistry (2010), 18(13), 4801-4811. [3]. Yauch, Robert L.; Gould, Stephen E.; Scales, Suzie J.; et al. A paracrine requirement for hedgehog signalling in cancer. Nature (London, United Kingdom) (2008), 455(7211), 406-410.