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9046-40-6

9046-40-6 structure
9046-40-6 structure
  • Name: Pectic acid
  • Chemical Name: (2S,3R,4S,5R)-6-[(2S,3R,4R,5R)-2-carboxy-6-[(2S,3R,4R,5R,6S)-2-carboxy-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
  • CAS Number: 9046-40-6
  • Molecular Formula: C18H26O19
  • Molecular Weight: 546.38800
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-08-24 21:46:46
  • Modify Date: 2025-08-25 17:54:04
  • Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease[2][3].
Name (2S,3R,4S,5R)-6-[(2S,3R,4R,5R)-2-carboxy-6-[(2S,3R,4R,5R,6S)-2-carboxy-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonyms Poly(1,4-|A-D-galacturonate)
|A-D-Polygalacturonic acid
Description Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease[2][3].
Related Catalog
In Vitro Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells[1]. Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining[2]. Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner[2]. Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining[2]. Cell Cycle Analysis[2] Cell Line: GH3/B6 cells Concentration: 1 mg/mL Incubation Time: 24 h Result: Induced sub G1 events, and DNA fragmentation, which was correlated with the number of the apoptotic cells.
In Vivo Pectic acid (25 and 100 mg/kg, oral gavage) increases colon length, downregulates disease activity index, histopathological score and proinflammatory cytokine levels in Ulcerative colitis (UC) mice[3]. Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice[3]. Animal Model: Ulcerative colitis (UC) mice[3] Dosage: 25, 100 mg/kg Administration: Oral gavage Result: Exhibited the longest colon, lowest DAI, and minimum histopathological score. Decreased the proinflammatory cytokines in the colonic tissue of UC mice. Animal Model: Ulcerative colitis (UC) mice[3] Dosage: 6.25, 12.5 mg/kg Administration: Intravenous injection Result: Decreased the spleen and thymus index. Restored the Th17/Treg balance in the spleen and lamina propria of UC mice. Improved the gut microbiota composition.
References

[1]. Delaram Eslimi, et al. Pectic acid effects on prolactin secretion in GH3/B6 rat pituitary cell line. Iran Biomed J. 2008 Jul;12(3):167-72.

[2]. Farnoosh Attari, et al. Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells. Iran Biomed J. 2009 Oct;13(4):229-36.

[3]. Jie Song, et al. Effects of oral administration and intravenous injection of polygalacturonic acid on the immunomodulation and gut microbiota in UC mice. Int J Biol Macromol. 2022 Sep 30;217:150-160.

Molecular Formula C18H26O19
Molecular Weight 546.38800
Exact Mass 546.10700
PSA 319.89000
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
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