479-98-1
479-98-1 structure
- Name: Aucubin
- Chemical Name: Aucubin
- CAS Number: 479-98-1
- Molecular Formula: C15H22O9
- Molecular Weight: 346.330
- Catalog: Biochemical Chinese herbal medicine ingredients
- Create Date: 2018-03-20 08:00:00
- Modify Date: 2026-06-30 15:28:16
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Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.IC50 value:Target:In vitro: Aucubin promotes neuronal differentiation and neurite outgrowth in neural stem cells cultured primarily from the rat embryonic hippocampus [1]. Aucubin significantly reversed the elevated gene and protein expression of MMP-3, MMP-9, MMP-13, iNOS, COX-2 and the production of NO induced by IL-1β challenge in rat chondrocytes [2]. In vivo:
| Name | Aucubin |
|---|---|
| Synonyms |
AUCUBIN hplc
EINECS 207-540-8 1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl-beta-D-glucopyranoside 1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c b-D-Glucopyranoside,(1S,4,5S,7aS)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl Aucubin //BP AUCUBOSIDE AUCUBINB-D-GLUCOPYRANOSIDE, (1S,4,5S,7AS)-1,4A,5,7A-TETRAHYDRO-5-HYDROXY-7-(HYDROXYMETHYL)CYCLOPENTA[C]PYRAN-1-YL MFCD00136026 B-D-GLUCOPYRANOSIDE, (1S,4,5S,7AS)-1,4A,5,7A-TETRAHYDRO-5-HYDROXY-7-(HYDROXYMETHYL)CYCLOPENTA[C]PYRAN-1-YL (2S,3R,4S,5S,6R)-2-{[(1S,4aR,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyr-1-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol RHINANTHIN Aucubin from Eucommia ulmoides Oliver [1S-(1alpha,4aalpha,5alpha,7aalpha)]-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl-beta-D-glucopyranoside 6-iaucubin β-D-Glucopyranoside, (1S,4,5S,7aS)-1,4a,5,7a b-D-Glucopyranoside, 1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl, [1S-(1a,4a,5a,7a)] (2S,3R,4S,5S,6R)-2-((1S,4,5R,7as)-5-hydroxy-7-hydroxymethyl-1,4A,5,7A-tetrahydro-cyclopenta[C]pyran-1-yloxy)-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol β-D-Glucopyranoside, (1S,4,5S,7aS)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl Aucubine-RM 1S-(1alpha,4aalpha,5alpha,7aalpha)-1,4a,5,7a-Tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl-beta-D-glucopyranoside β-D-Glucopyranoside, (1S,4aR,5S,7aS)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl [1S-(1a,4aa,5a,7a)]-1,4a,5,7a-Tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl-b-D-glucopyranoside Aucubin Standd (2S,3R,4S,5S,6R)-2-{[(1S,4aR,5S,7aS)-5-Hydroxy-7-(hydroxyméthyl)-1,4a,5,7a-tétrahydrocyclopenta[c]pyran-1-yl]oxy}-6-(hydroxyméthyl)tétrahydro-2H-pyran-3,4,5-triol Rhimanthin tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta 2-[[(1S,4,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol (2S,3R,4S,5S,6R)-2-{[(1S,4,5S,7aS)-5-hydroxy-7-(hydroxyMethyl)-1H,4aH,5H,7aH-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxyMethyl)oxane-3,4,5-triol [c]pyran-1-yl Aucubosid Nsc407293 (2S,3R,4S,5S,6R)-2-{[(1S,4aR,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Rhimantin Aucubin -1 (1S,4aR,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl β-D-glucopyranoside (1S,4,5S,7aS)-1,4a,5,7a-Tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl β-D-glucopyranoside (2S,3R,4S,5S,6R)-2-(((1S,4,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Aucubigenin 1-O-β-D-glucopyranoside AUCUBIN Aucubin, 10 mM in DMSO (1S,4aR,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyr-1-yl-β-D-glucopyranoside Aids-031379 AUCUBIN(P) Rhinanthin (2S,3R,4S,5S,6R)-2-[[(1S,4,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol [(1S)-1,4aα,5,7aα-Tetrahydro-5α-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1α-yl]β-D-glucopyranoside Aucubin std Aids031379 |
| Description | Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.IC50 value:Target:In vitro: Aucubin promotes neuronal differentiation and neurite outgrowth in neural stem cells cultured primarily from the rat embryonic hippocampus [1]. Aucubin significantly reversed the elevated gene and protein expression of MMP-3, MMP-9, MMP-13, iNOS, COX-2 and the production of NO induced by IL-1β challenge in rat chondrocytes [2]. In vivo: |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 669.0±55.0 °C at 760 mmHg |
| Melting Point | 180 - 184ºC |
| Molecular Formula | C15H22O9 |
| Molecular Weight | 346.330 |
| Flash Point | 358.4±31.5 °C |
| Exact Mass | 346.126373 |
| PSA | 149.07000 |
| LogP | -3.17 |
| Vapour Pressure | 0.0±4.6 mmHg at 25°C |
| Index of Refraction | 1.660 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Risk Phrases | R22 |
| Safety Phrases | S22-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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479-98-1 |
| Literature: Cachet, Xavier; Deguin, Brigitte; Koch, Michel; Makhlouf, Kader; Tillequin, Francois Journal of Natural Products, 1999 , vol. 62, # 2 p. 400 - 402 |
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479-98-1 |
| Literature: Bianco; Passacantilli; Nicoletti; Alves de Lima Tetrahedron, 1982 , vol. 38, # 3 p. 359 - 362 |
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479-98-1 |
| Literature: Bianco; Passacantilli; Nicoletti; Alves de Lima Tetrahedron, 1982 , vol. 38, # 3 p. 359 - 362 |
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479-98-1 |
| Literature: Bianco; Passacantilli; Nicoletti; Alves de Lima Tetrahedron, 1982 , vol. 38, # 3 p. 359 - 362 |
|
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479-98-1 |
| Literature: Weinges, Klaus; Ziegler, Hans Juergen Liebigs Annalen der Chemie, 1990 , # 7 p. 715 - 717 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |