126-17-0
126-17-0 structure
- Name: Solasodine
- Chemical Name: Solasodine
- CAS Number: 126-17-0
- Molecular Formula: C27H43NO2
- Molecular Weight: 413.636
- Catalog: Natural product Steroidal compound
- Create Date: 2018-05-31 08:00:00
- Modify Date: 2026-07-03 11:54:05
-
Solasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and human myeloid leukemia cell line (U937).IC50 Value: 12.17 ± 3.3 uM (Hela cell line)[1]Target: Anticancerin vitro: Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed specific neuronal markers and displayed important axonal formation that continued growing even 30 days after treatment [2].in vivo: A 2-week infusion ofsolasodine into the left ventricle of the rat brain followed by a 3-week washout resulted in a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining, demonstrating the proliferative and differentiating properties of solasodine on neuronal progenitors. Solasodine treatment in rats resulted in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells, suggesting a possible role played by neurosteroid production in solasodine-induced neurogenesis. In GAD65-GFP mice that express the green fluorescent protein under the control of the glutamic acid decarboxylase 65-kDa promoter, solasodine treatment increased the number of GABAergic progenitors and neuroblasts generated in the subventricular zone and present in the olfactory migratory tract [2]. intraperitoneal (i.p.) injection of solasodine (25 mg/kg) significantly delayed (p < 0.01) latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. In the MES model, solasodine significantly reduced (p < 0.001) duration of HLTE at 25, 50, and 100 mg/kg, i.p. in a dose-dependent manner [3]. Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides [4].
| Name | Solasodine |
|---|---|
| Synonyms |
Salasdine
Solanearpidine Sosasodine Solancpine Solanum nium L Solasodine, 10 mM in DMSO Solancarpidine Solasod-5-en-3b-ol Solasodine extrapure MFCD00037844 Spirosol-5-en-3-ol, (3beta,22alpha,25R) EINECS 204-774-2 Solasod-5-en-3-β-ol delta5-20betaf,22alphaf,25alphaf,27-azaspirosten-3beta-ol Solanidine-S PURAPURIDINE Solasod-5-en-3β-ol (7CI,8CI) D5-20bF,22aF,25aF,28-azaspirosten-3b-ol 5-SOLASODEN-3BETA-OL Solasodin SOLASOD-5-EN-3BETA-OL Salasod-5-en-3β-ol Spirosol-5-en-3-ol, (3β,22α,25R) (3b,22a,25R)-Spirosol-5-en-3-ol (-)-Solasodine SOLANCPIDINE Solasod-5-en-3β-ol (3β,22α,25R)-Spirosol-5-en-3-ol (3beta,22alpha,25r)-spirosol-5-en-3-o Spirosol-5-en-3-ol Solasod-5-en-3β-ol (8CI) Purapuridine SOLANI NIGERI HERBA (2'R,4S,5'R,6,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol Nsc178260 Solasodine hydrochloride base Solasodine-RM (4S,5'R,6,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-Tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol Solasodine - Bio-X Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-piperidine], spirosol-5-en-3-ol deriv Salasodine Fluoroestradiol Impurity 36 SOLASODINE |
| Description | Solasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and human myeloid leukemia cell line (U937).IC50 Value: 12.17 ± 3.3 uM (Hela cell line)[1]Target: Anticancerin vitro: Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed specific neuronal markers and displayed important axonal formation that continued growing even 30 days after treatment [2].in vivo: A 2-week infusion ofsolasodine into the left ventricle of the rat brain followed by a 3-week washout resulted in a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining, demonstrating the proliferative and differentiating properties of solasodine on neuronal progenitors. Solasodine treatment in rats resulted in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells, suggesting a possible role played by neurosteroid production in solasodine-induced neurogenesis. In GAD65-GFP mice that express the green fluorescent protein under the control of the glutamic acid decarboxylase 65-kDa promoter, solasodine treatment increased the number of GABAergic progenitors and neuroblasts generated in the subventricular zone and present in the olfactory migratory tract [2]. intraperitoneal (i.p.) injection of solasodine (25 mg/kg) significantly delayed (p < 0.01) latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. In the MES model, solasodine significantly reduced (p < 0.001) duration of HLTE at 25, 50, and 100 mg/kg, i.p. in a dose-dependent manner [3]. Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides [4]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 537.9±50.0 °C at 760 mmHg |
| Melting Point | 284 °C (dec.)(lit.) |
| Molecular Formula | C27H43NO2 |
| Molecular Weight | 413.636 |
| Flash Point | 279.1±30.1 °C |
| Exact Mass | 413.329376 |
| PSA | 41.49000 |
| LogP | 5.78 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.572 |
| Storage condition | 2-8°C |
| Water Solubility | 200 g/L (25 ºC) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Safety Phrases | S22-S24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | WF1300000 |
| Precursor 8 | |
|---|---|
| DownStream 3 | |
