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  • DC Chemicals Limited
  • China
  • Product Name: Tegaserod
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

145158-71-0

145158-71-0 structure
145158-71-0 structure
  • Name: Tegaserod
  • Chemical Name: tegaserod
  • CAS Number: 145158-71-0
  • Molecular Formula: C16H23N5O
  • Molecular Weight: 301.387
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2018-07-14 19:44:24
  • Modify Date: 2024-01-02 14:50:14
  • Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1].

Name tegaserod
Synonyms (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide
Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2E)-
tegaserodum
(2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide
Zelmac
MFCD06660144
Tegaserode
(2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N'-pentylhydrazinecarboximidamide
Tegaserod
Description Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1].
Related Catalog
Target

5-HT4 Receptor

In Vitro Tegaserod (1.5 and 3 μM) induces apoptosis in the B16F10 murine melanoma cell line as well as several human melanoma cell lines[1]. Cell Viability Assay[1] Cell Line: B16F10 cells Concentration: 78 nM-10 μM Incubation Time: 72 hours Result: Had anti-cancer activity with IC50 values in the low micromolar range as assessed by MTT assay following 72 h of exposure.
In Vivo Tegaserod (5 mg/kg) delays tumor growth, reduces metastases, increases survival and suppresses p-S6 in vivo[1]. Animal Model: C57BL/6 J mice were subcutaneously injected with B16F10 cells[1] Dosage: 5 mg/kg Administration: Administered intraperitoneally (i.p.) daily for five consecutive days Result: Treatment significantly decreased tumor growth and resulted in only slight decreases in weight following treatment.
References

[1]. Wei Liu, et al. Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications. J Exp Clin Cancer Res. 2020 Feb 21;39(1):38.

Density 1.2±0.1 g/cm3
Boiling Point 470.6±48.0 °C at 760 mmHg
Melting Point 180-183ºC
Molecular Formula C16H23N5O
Molecular Weight 301.387
Flash Point 238.4±29.6 °C
Exact Mass 301.190247
PSA 159.89000
LogP 2.91
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.597
Hazard Codes Xi
Risk Phrases R20/21/22
Safety Phrases S36/37
HS Code 2933990090

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145158-71-0 structure

145158-71-0

Literature: WO2005/14544 A1, ; Page/Page column 10-11 ;

~90%

145158-71-0 structure

145158-71-0

Literature: EP1955998 A1, ; Page/Page column 3 ;
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%