68-88-2
68-88-2 structure
- Name: Hydroxyzine
- Chemical Name: hydroxyzine
- CAS Number: 68-88-2
- Molecular Formula: C21H27ClN2O2
- Molecular Weight: 374.90400
- Catalog: API Nervous system medication Anxiolytic
- Create Date: 2018-09-15 17:44:28
- Modify Date: 2026-07-01 13:33:55
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Hydroxyzine is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 ?M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine significantly reduces the efflux and approximately 2.4 ?g/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen [3].Hydroxyzine (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats [3]. Hydroxyzine (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats [4].
| Name | hydroxyzine |
|---|---|
| Synonyms |
Hydroxyzyne
Tran-Q HYDROXYZINE;NSC 169188;U.C.B EQUIPOISE / HYDROXYZINE Atazoid Aterax 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine Hydroxycine 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine Hydroxyzin Ethanol, 2-[2-[4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl]ethoxy] Neurozina 1-(p-Chloro-α-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine Traquizine Equipoise 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)-piperazin-1-yl)ethoxy)etha Vistil 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyet N-(4-Chlorobenzhydryl)-N'-(hydroxyethoxyethyl)piperazine Ethanol, 2-[2-[4-(4-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (6CI) Ataxoid Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy] Pamazone Atax base Hydroksyzyny Nevrolaks U.CB Hydroxine Hydroxyzine (base and/or unspecified salts) Hydroxizine Hychotine Penteral 2-(2-(4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl)ethoxy)ethanol 2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol Atax Plaxidol Paxistil Idrossizina Placidol Atox 1-(p-Chloro-a-phenylbenzyl)-4-[2-(2-hydroxyethoxy)ethyl)]piperazine UCB-4492 Atazina Ata 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol EINECS 200-693-1 Tranquizine neo-Calma 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol 2-(2-(4-(4-chlorobenzhydryl)piperazin-1-yl)ethoxy)ethanol Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (8CI) Deinait Vespaz-Wirkstoff U.C.B 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-((2-hydroxyethoxy)ethyl)piperazine |
| Description | Hydroxyzine is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 ?M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine significantly reduces the efflux and approximately 2.4 ?g/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen [3].Hydroxyzine (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats [3]. Hydroxyzine (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats [4]. |
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| Related Catalog | |
| References |
| Boiling Point | 220 (0.5 torr) |
|---|---|
| Melting Point | 190°C |
| Molecular Formula | C21H27ClN2O2 |
| Molecular Weight | 374.90400 |
| Exact Mass | 374.17600 |
| PSA | 35.94000 |
| LogP | 2.93170 |
| Storage condition | 2-8℃ |
| Water Solubility | < 700 MG/ML |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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68-88-2 |
| Literature: Industrie Chimique Belge, , vol. 19, p. 1176,1181 |
| Precursor 1 | |
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| DownStream 0 | |
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |