80573-04-2
80573-04-2 structure
- Name: Balsalazide
- Chemical Name: balsalazide
- CAS Number: 80573-04-2
- Molecular Formula: C17H15N3O6
- Molecular Weight: 357.318
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2018-06-29 12:49:05
- Modify Date: 2024-01-02 17:19:55
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Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
| Name | balsalazide |
|---|---|
| Synonyms |
BALSALAZIDE SODIUM
balsalazido (3E)-3-({4-[(2-Carboxyethyl)carbamoyl]phenyl}hydrazono)-6-oxo-1,4-cyclohexadiene-1-carboxylic acid Balsalazide BALSALAZIDE DISODIUM SALT 1,4-Cyclohexadiene-1-carboxylic acid, 3-[2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]hydrazinylidene]-6-oxo-, (3E)- BALSALZIDE DISODIUM |
| Description | Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. |
|---|---|
| Related Catalog | |
| Target |
STAT3 IL-6 |
| In Vivo | At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2]. |
| Animal Admin | Mice[1] C57B/L6J mice are randomly divided into four groups: CAC group, Balsalazide (BSZ) group (300 mg/kg), VSL#3 group, and BSZ+VSL#3 group. After two weeks, the AOM/DSS model is induced by AOM injection followed by two cycles of 2% DSS[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 254-255ºC |
| Molecular Formula | C17H15N3O6 |
| Molecular Weight | 357.318 |
| Exact Mass | 357.096100 |
| PSA | 148.65000 |
| LogP | 1.00 |
| Index of Refraction | 1.650 |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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