Balsalazide

Modify Date: 2024-01-02 17:19:55

Balsalazide structure	Common Name	Balsalazide
	CAS Number	80573-04-2	Molecular Weight	357.318
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₅N₃O₆	Melting Point	254-255ºC
	MSDS	N/A	Flash Point	N/A

Use of Balsalazide

Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

Name	balsalazide
Synonym	More Synonyms

Description	Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
Target	STAT3 IL-6
In Vivo	At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].
Animal Admin	Mice[1] C57B/L6J mice are randomly divided into four groups: CAC group, Balsalazide (BSZ) group (300 mg/kg), VSL#3 group, and BSZ+VSL#3 group. After two weeks, the AOM/DSS model is induced by AOM injection followed by two cycles of 2% DSS[1].
References	[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. [2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

Density	1.4±0.1 g/cm3
Melting Point	254-255ºC
Molecular Formula	C₁₇H₁₅N₃O₆
Molecular Weight	357.318
Exact Mass	357.096100
PSA	148.65000
LogP	1.00
Index of Refraction	1.650
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG4974900

CHEMICAL NAME :: Benzoic acid, 5-((4-(((2-carboxyethyl)amino)carbonyl)phenyl)azo)-2- hydroxy-, (E)-

CAS REGISTRY NUMBER :: 80573-04-2

LAST UPDATED :: 199406

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H15-N3-O6

MOLECULAR WEIGHT :: 357.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,313,1984

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,313,1984

Risk Phrases	R20/21/22
Safety Phrases	S36/37

BALSALAZIDE SODIUM

balsalazido

(3E)-3-({4-[(2-Carboxyethyl)carbamoyl]phenyl}hydrazono)-6-oxo-1,4-cyclohexadiene-1-carboxylic acid

Balsalazide

BALSALAZIDE DISODIUM SALT

1,4-Cyclohexadiene-1-carboxylic acid, 3-[2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]hydrazinylidene]-6-oxo-, (3E)-

BALSALZIDE DISODIUM

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China
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China
Product Name: Balsalazide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Balsalazide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: $131/10mM*1mLinDMSO

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Balsalazide

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Balsalazide Biological Activity

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