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353-09-3

353-09-3 structure
353-09-3 structure
  • Name: RGX-202
  • Chemical Name: 3-guanidinopropanoic acid
  • CAS Number: 353-09-3
  • Molecular Formula: C4H9N3O2
  • Molecular Weight: 131.133
  • Catalog: Chemical reagent Organic reagent fatty acid
  • Create Date: 2018-04-17 08:00:00
  • Modify Date: 2024-01-04 16:36:23
  • RGX-202 is an oral small-molecule SLC6A8 transporter inhibitor. RGX-202 robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 can be used for the research of cancer[1].
Name 3-guanidinopropanoic acid
Synonyms EINECS 206-530-0
β-Alanine, N-(aminoiminomethyl)-
3-(diaminomethylideneamino)propanoic acid
n-carbamimidoyl-|A-alanine
beta-Guanidinopropionic acid
3-Guanidinopropanoate
3-carbamimidamidopropanoic acid
N-Carbamimidoyl-β-alanine
N-(Aminomethyl)-β-alanine
MFCD00045939
Guanidinopropionic acid
3-Guanidinopropionic Acid
β-Guanidinopropionic acid
b-Guanidinopropionate
3-Guanidinopropanoic acid
3-guanidinepropionic acid
Description RGX-202 is an oral small-molecule SLC6A8 transporter inhibitor. RGX-202 robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 can be used for the research of cancer[1].
Related Catalog
Target

Human Endogenous Metabolite
In Vitro RGX-202 (10 μM; 96 hours) reduces cell growth, and reveals a nearly complete depletion of phosphocreatine (>99%), greater than 79% reduction in cellular creatine and a substantial (46%) reduction in intracellular ATP levels relative to control cells in hypoxia[1].
In Vivo RGX-202 (800 mg/kg; p.o. for 35 days) reduces UN-KPC-961 pancreatic tumoral creatine levels in B6129SF1/J mice[1]. RGX-202 (approximately 650 mg/kg; i.p. daily for 14 days) treatment reduces Lvm3b cells liver metastatic colonization by eightfold in NOD-SCID mice[1]. Animal Model: UN-KPC-961 pancreatic tumor-bearing B6129SF1/J mice[1] Dosage: 800 mg/kg Administration: p.o. for 35 days Result: Suppressed tumoral d3-creatine import by 50% at 800 mg/kg. Animal Model: 6- to 9-week-old C57BL/6J male wild-type mice[1] Dosage: 100, 250, 500 mg/KG in sterile 0.9% NaCl Administration: p.o. for 35 days Result: Inhibited tissue uptake of d3-creatine in a dose-dependent manner by up to 75% at 500 mg/kg.
References

[1]. Kurth I, et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021 Oct 8;7(41):eabi7511.
Density 1.5±0.1 g/cm3
Boiling Point 299.1±42.0 °C at 760 mmHg
Melting Point 222 °C (dec.)(lit.)
Molecular Formula C4H9N3O2
Molecular Weight 131.133
Flash Point 134.7±27.9 °C
Exact Mass 131.069473
PSA 99.20000
LogP -1.68
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.575
Storage condition −20°C
Material Safety Data Sheet
Section1. Identification of the substance
Product Name: 3-Guanidinopropionic acid
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:3-Guanidinopropionic acid
CAS number:353-09-3
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C4H9N3O2
Molecular weight: 131.1
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AY3157500
HS Code 2925290090
1184-90-3 structure

1184-90-3
107-95-9 structure

107-95-9

~75%

353-09-3 structure

353-09-3
Literature: Synthesis, , # 9 p. 777 - 779
1758-73-2 structure

1758-73-2
107-95-9 structure

107-95-9

~74%

353-09-3 structure

353-09-3
Literature: Synthesis, , # 12 p. 1656 - 1658
1221685-79-5 structure

1221685-79-5

~%

353-09-3 structure

353-09-3
Literature: Journal of Molecular Biology, , vol. 396, # 4 p. 870 - 882
2986-19-8 structure

2986-19-8
107-95-9 structure

107-95-9

~%

353-09-3 structure

353-09-3
Literature: Bulletin de la Societe Chimique de France, , p. 182
2440-60-0 structure

2440-60-0
107-95-9 structure

107-95-9

~%

353-09-3 structure

353-09-3
Literature: Zhurnal Obshchei Khimii, , vol. 18, p. 2028 Chem.Abstr., , p. 3793
420-04-2 structure

420-04-2
107-95-9 structure

107-95-9

~%

353-09-3 structure

353-09-3
Literature: Chemische Berichte, , vol. 8, p. 1263
107-95-9 structure

107-95-9

~51%

353-09-3 structure

353-09-3
Literature: Tetrahedron Letters, , vol. 43, # 8 p. 1401 - 1403
HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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title: CAS No. 353-09-3 | Chemsrc address: https://m.chemsrc.com/en/baike/325316.html

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