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118072-93-8

118072-93-8 structure
118072-93-8 structure
  • Name: Zoledronic acid
  • Chemical Name: zoledronic acid
  • CAS Number: 118072-93-8
  • Molecular Formula: C5H10N2O7P2
  • Molecular Weight: 272.090
  • Catalog: Organic raw materials Organic phosphine compound
  • Create Date: 2018-02-08 08:00:00
  • Modify Date: 2024-01-02 16:58:00
  • Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.

Name zoledronic acid
Synonyms zoledronate
Zoledronic acid monohydrate
P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate
acide [1-hydroxy-2-(1H-imidazol-1-yl)éthane-1,1-diyl]bis(phosphonique)
hydrogen [1-hydroxy-2-(1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate
[1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid)
Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-
[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
Zometa,Zomera,Aclasta and Reclast
MFCD00867791
[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid
[1-Hydroxy-2-(1H-imidazol-1-yl)ethan-1,1-diyl]bis(phosphonsäure)
Zoledronic acid
Phosphonic acid (P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis
[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid
(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid
2-(Imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic Acid
[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
Description Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.
Related Catalog
In Vitro Zoledronic Acid induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].
References

[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6.

[2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8.

Density 2.1±0.1 g/cm3
Boiling Point 764.0±70.0 °C at 760 mmHg
Melting Point 193-2040ºC
Molecular Formula C5H10N2O7P2
Molecular Weight 272.090
Flash Point 415.8±35.7 °C
Exact Mass 271.996338
PSA 172.73000
LogP -2.28
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.719
Hazard Codes Xi: Irritant;
Risk Phrases R21/22
Safety Phrases 24/25-36/37/39
HS Code 2933290090

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Literature: Synthon B.V. Patent: EP2192126 A1, 2010 ; Location in patent: Page/Page column 9 ;

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118072-93-8

Literature: Letters in Drug Design and Discovery, , vol. 9, # 4 p. 345 - 351

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Literature: Acta Crystallographica Section C: Crystal Structure Communications, , vol. 69, # 3 p. 263 - 266

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118072-93-8

Literature: Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 188, # 1-3 p. 39 - 41

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118072-93-8 structure

118072-93-8

Literature: Russian Journal of General Chemistry, , vol. 82, # 6 p. 1178 - 1179,2 Zhurnal Obshchei Khimii, , vol. 82, # 6 p. 1044 - 1045,2
HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%