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  • Product Name: Zileuton
  • Price: $250.0/100mg $500.0/250mg $1000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
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111406-87-2

111406-87-2 structure
111406-87-2 structure
  • Name: Zileuton
  • Chemical Name: zileuton
  • CAS Number: 111406-87-2
  • Molecular Formula: C11H12N2O2S
  • Molecular Weight: 236.290
  • Catalog: API Respiratory medication Asthma
  • Create Date: 2018-07-23 20:45:05
  • Modify Date: 2024-01-02 20:00:55
  • Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
Name zileuton
Synonyms Leutml
MFCD00866097
N-hydroxy-N-{1-(benzo[b]thien-2-yl)ethyl}urea
Zyflo
1-[1-(1-Benzothiophen-2-yl)ethyl]-1-hydroxyurea
1-(1-(Benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea
Urea, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-
1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea
Leutrol
Zileuton
Zyfl
Description Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
Related Catalog
In Vitro In anti-CD3-treated cells, IL-2 decreases in zileuton-treated and untreated cells with increasing incubation time. Zileuton likely reduces IL-2 levels by inhibiting 5-lipoxygenase, hence leukotriene B4 production, an IL-2 inducer[2].
In Vivo In zileuton (5 mg/kg, p.o.) treated I/R rat, the effect of zileuton to decrease NF-κB expression does not change significantly in the presence of COX inhibitors, and the group reveals significantly lower level of NF-κB staining. Zileuton (5 mg/kg, p.o.) treatment given to I/R rats decreases apoptotic index significantly. Zileuton has no significant effect on increased serum TNF-α levels in I/R group[1]. Zileuton (1,200 mg/kg) inhibits the polyp formation in APCΔ468 colon and small intestine. Zileuton treatment inhibits the proliferation rates of non epithelial cells in polyps, and increases the apoptosis rates in polyps in rat. There is significant increase in the number of apoptotic cells in the Zileuton-treated cells both in small intestine and in the colon. The reduced proliferation rate may significantly contribute to the reduction of polyposis in both the small intestine and colon of Zileuton-fed APCΔ468 mice[3].
Animal Admin Rats: Rats are randomized into 6 groups (n=12 per group): sham I/R group, I/R group, zileuton+I/R group, zileuton+indomethacin+I/R group, zileuton+ketorolac+I/R group, and zileuton+nimesulide+I/R group. 5-LOX inhibitor zileuton (5 mg/kg, orally twice daily) is given alone or with non-selective COX inhibitor indomethacin (5 mg/kg, intraperitoneally), selective COX-1 inhibitor ketorolac (10 mg/kg, orally) or selective COX-2 inhibitor nimesulide (10 mg/kg, subcutaneously). COX inhibitors are given 15 minutes before zileuton administration. All drugs are given for 3 days prior to I/R or sham I/R procedure. Dose of zileuton (5 mg/kg, twice daily) is used in this study. Rats in sham I/R group receive the vehicle of zileuton orally. Zileuton is dissolved in dimethyl sulfoxide (DMSO) and further dilutions are made using saline to achieve a final DMSO concentration of 1%.
References

[1]. Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10

[2]. Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner

[3]. Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10(3):e0121402
Density 1.4±0.1 g/cm3
Boiling Point 449.4±47.0 °C at 760 mmHg
Melting Point 157-158°C
Molecular Formula C11H12N2O2S
Molecular Weight 236.290
Flash Point 225.6±29.3 °C
Exact Mass 236.061951
PSA 94.80000
LogP 3.74
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.704
Storage condition Store at +4°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 22-36
Safety Phrases 26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 111406-87-2 | Chemsrc address: https://m.chemsrc.com/en/baike/330753.html

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