19046-78-7
19046-78-7 structure
- Name: Adenylosuccinic acid
- Chemical Name: N6-(1,2-dicarboxyethyl)-AMP
- CAS Number: 19046-78-7
- Molecular Formula: C14H18N5O11P
- Molecular Weight: 463.29300
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-09-06 12:45:20
- Modify Date: 2024-01-02 12:42:13
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Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1].
| Name | N6-(1,2-dicarboxyethyl)-AMP |
|---|---|
| Synonyms |
ADENYLOSUCCINIC ACID
N(6)-(1,2-dicarboxyethyl)-AMP Aspartyl-AMP adenylosuccnic acid L-Aspartic acid 4-(5'-adenylyl) ester Adenylobernsteinsaeure(L-) Adenylsuccinic acid aspartyl adenylate N6-(1,2-dicarboxy-ethyl)-[5']adenylic acid adenylosuccinic acid free acid |
| Description | Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: ribonucleoside monophosphate[1] |
| In Vivo | Adenylosuccinic acid (oral administration; 3-3000 µg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca2+ content of mdx tibialis anterior[1]. Animal Model: C57Bl/10ScSn (normal wild-type strain; Con) and C57Bl/10mdx (mdx) mice[1] Dosage: 3 µg/mL, 30 µg/mL, 300 µg/mL, 3000 µg/mL Administration: 3 µg/mL for 3 days and 30 µg/mL for the next 4 days, and 300 µg/mL for one week, and then 3000 µg/mL for 6 weeks Result: Ameliorated the symptoms of murine duchenne muscular dystrophy. |
| References |
| Density | 2.19g/cm3 |
|---|---|
| Boiling Point | 921.9ºC at 760mmHg |
| Molecular Formula | C14H18N5O11P |
| Molecular Weight | 463.29300 |
| Flash Point | 511.3ºC |
| Exact Mass | 463.07400 |
| PSA | 256.49000 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.833 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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19046-78-7 |
| Literature: Davey Nature (London, United Kingdom), 1959 , vol. 183, p. 995 Archives of Biochemistry, 1961 , vol. 95, p. 296,298 |
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19046-78-7 |
| Literature: Carter; Cohen Journal of Biological Chemistry, 1956 , vol. 222, p. 17,18,22 |
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19046-78-7 |
| Literature: Carter; Cohen Journal of Biological Chemistry, 1956 , vol. 222, p. 17,18,22 |
