Adenylosuccinic acid
Adenylosuccinic acid structure
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Common Name | Adenylosuccinic acid | ||
|---|---|---|---|---|
| CAS Number | 19046-78-7 | Molecular Weight | 463.29300 | |
| Density | 2.19g/cm3 | Boiling Point | 921.9ºC at 760mmHg | |
| Molecular Formula | C14H18N5O11P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 511.3ºC | |
Use of Adenylosuccinic acidAdenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1]. |
| Name | N6-(1,2-dicarboxyethyl)-AMP |
|---|---|
| Synonym | More Synonyms |
| Description | Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1]. |
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| Related Catalog | |
| Target |
IC50: ribonucleoside monophosphate[1] |
| In Vivo | Adenylosuccinic acid (oral administration; 3-3000 µg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca2+ content of mdx tibialis anterior[1]. Animal Model: C57Bl/10ScSn (normal wild-type strain; Con) and C57Bl/10mdx (mdx) mice[1] Dosage: 3 µg/mL, 30 µg/mL, 300 µg/mL, 3000 µg/mL Administration: 3 µg/mL for 3 days and 30 µg/mL for the next 4 days, and 300 µg/mL for one week, and then 3000 µg/mL for 6 weeks Result: Ameliorated the symptoms of murine duchenne muscular dystrophy. |
| References |
| Density | 2.19g/cm3 |
|---|---|
| Boiling Point | 921.9ºC at 760mmHg |
| Molecular Formula | C14H18N5O11P |
| Molecular Weight | 463.29300 |
| Flash Point | 511.3ºC |
| Exact Mass | 463.07400 |
| PSA | 256.49000 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.833 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Adenylosuccinic acid CAS#:19046-78-7 |
| Literature: Davey Nature (London, United Kingdom), 1959 , vol. 183, p. 995 Archives of Biochemistry, 1961 , vol. 95, p. 296,298 |
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Adenylosuccinic acid CAS#:19046-78-7 |
| Literature: Carter; Cohen Journal of Biological Chemistry, 1956 , vol. 222, p. 17,18,22 |
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Adenylosuccinic acid CAS#:19046-78-7 |
| Literature: Carter; Cohen Journal of Biological Chemistry, 1956 , vol. 222, p. 17,18,22 |
CAS#:75-07-0
CAS#:4542-23-8|
The RimL transacetylase provides resistance to translation inhibitor microcin C.
J. Bacteriol. 196(19) , 3377-85, (2014) Peptide-nucleotide antibiotic microcin C (McC) is produced by some Escherichia coli strains. Inside a sensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which ... |
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Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs.
Bioorg. Med. Chem. 13(1) , 69-75, (2005) Three nonhydrolyzable aspartyl adenylate analogs have been prepared and tested as inhibitors of E. coli aspartyl-tRNA synthetase. 5'-O-[N-(L-Aspartyl)sulfamoyl]adenosine is a potent competitive inhibi... |
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MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic.
J. Biol. Chem. 285(17) , 12662-9, (2010) The heptapeptide-nucleotide microcin C (McC) is a potent inhibitor of enteric bacteria growth. McC is excreted from producing cells by the MccC transporter. The residual McC that remains in the produc... |
| ADENYLOSUCCINIC ACID |
| N(6)-(1,2-dicarboxyethyl)-AMP |
| Aspartyl-AMP |
| adenylosuccnic acid |
| L-Aspartic acid 4-(5'-adenylyl) ester |
| Adenylobernsteinsaeure(L-) |
| Adenylsuccinic acid |
| aspartyl adenylate |
| N6-(1,2-dicarboxy-ethyl)-[5']adenylic acid |
| adenylosuccinic acid free acid |