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2445-83-2

2445-83-2 structure
2445-83-2 structure
  • Name: 7-Methylcoumarin
  • Chemical Name: 7-methylchromen-2-one
  • CAS Number: 2445-83-2
  • Molecular Formula: C10H8O2
  • Molecular Weight: 160.17
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-05-27 08:00:00
  • Modify Date: 2024-01-02 19:49:30
  • 7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect[1].

Name 7-methylchromen-2-one
Synonyms Coumarin, 7-methyl-
7-methyl-coumarin
2H-1-Benzopyran-2-one, 7-methyl-
7-Methyl-2H-1-benzopyran-2-one
7-Methyl-2H-chromen-2-one
2H-1-Benzopyran-2-one,7-methyl
7-Methylcoumarin
EINECS 219-499-3
7-Methyl-cumarin
COUMARIN,7-METHYL
7-Methylchromen-2-one
7-methyl-chromen-2-one
MFCD00006880
Description 7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect[1].
Related Catalog
References

[1]. Sancheti S, et, al. Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36(1):42-7.

Density 1.2±0.1 g/cm3
Boiling Point 313.1±0.0 °C at 760 mmHg
Melting Point 128-130 °C(lit.)
Molecular Formula C10H8O2
Molecular Weight 160.17
Flash Point 125.9±19.5 °C
Exact Mass 160.052429
PSA 30.21000
LogP 1.85
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.583

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN7792100
CHEMICAL NAME :
Coumarin, 7-methyl-
CAS REGISTRY NUMBER :
2445-83-2
BEILSTEIN REFERENCE NO. :
0122625
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H8-O2
MOLECULAR WEIGHT :
160.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
258 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,186,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7980 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases 23/24/25
Safety Phrases S1-S13-S45
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS GN7792100
HS Code 2932209090
HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%