7-Methylcoumarin

Modify Date: 2025-08-22 19:48:15

7-Methylcoumarin structure	Common Name	7-Methylcoumarin
	CAS Number	2445-83-2	Molecular Weight	160.17
	Density	1.2±0.1 g/cm3	Boiling Point	313.1±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈O₂	Melting Point	128-130 °C(lit.)
	MSDS	Chinese USA	Flash Point	125.9±19.5 °C

Use of 7-Methylcoumarin

7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect[1].

Name	7-methylchromen-2-one
Synonym	More Synonyms

Description	7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Sancheti S, et, al. Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36(1):42-7.

Density	1.2±0.1 g/cm3
Boiling Point	313.1±0.0 °C at 760 mmHg
Melting Point	128-130 °C(lit.)
Molecular Formula	C₁₀H₈O₂
Molecular Weight	160.17
Flash Point	125.9±19.5 °C
Exact Mass	160.052429
PSA	30.21000
LogP	1.85
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.583
InChIKey	DLHXRDUXNVEIEY-UHFFFAOYSA-N
SMILES	Cc1ccc2ccc(=O)oc2c1

7-Methylcoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN7792100

CHEMICAL NAME :: Coumarin, 7-methyl-

CAS REGISTRY NUMBER :: 2445-83-2

BEILSTEIN REFERENCE NO. :: 0122625

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H8-O2

MOLECULAR WEIGHT :: 160.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 258 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,186,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7980 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	23/24/25
Safety Phrases	S1-S13-S45
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	GN7792100
HS Code	2932209090

Precursor 10
CAS#:698-27-1 2-Hydroxy-4-met... CAS#:927-80-0 Ethoxyethyne CAS#:617-48-1 (±)-Malic Acid CAS#:108-39-4 m-Cresol
CAS#:292638-85-8 acrylic acid me... CAS#:141-32-2 butyl acrylate CAS#:591-24-2 UNII:255L4HTY2B CAS#:115560-73-1 3-hydroxy-3-(2-...
CAS#:57234-27-2 1-(methoxymetho... CAS#:108-24-7 Ethanoic anhydride
DownStream 7
CAS#:50-85-1 2-Hydroxy-4-met... CAS#:50779-65-2 6-Methyl-benzof... CAS#:20921-01-1 7-methylchroman... CAS#:17397-70-5 Coumarin-7-carb...
CAS#:53666-75-4 7-methyl-6-nitr... CAS#:848352-37-4 7-methyl-3,6-di... CAS#:53878-12-9 7-(bromomethyl)...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001)

A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main compone...

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes.

Xenobiotica 46 , 14-24, (2016)

1. Information about the metabolism of compounds is essential in drug discovery and development, risk assessment of chemicals and further development of predictive methods. 2. In vitro and in silico m...

Name: Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM afte...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1913201

Name: Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM afte...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1913200

Name: Antioxidant activity assessed as hydroxyl radical scavenging activity at 100 uM after...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1913202

Name: Compound was evaluated for in vitro inhibition of beta-glucuronidase at 0.1 mM concen...
Source: ChEMBL
Target: Beta-glucuronidase
External Id: CHEMBL648353

Name: Interaction percent with DPPH after 20 minutes was determined at 0.2 mM concentration
Source: ChEMBL
Target: N/A
External Id: CHEMBL847001

Name: Inhibition of soybean lipoxygenase assessed as conversion of sodium linoleate to 13-h...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1913204

Name: Compound was evaluated for in vitro inhibition of beta-glucuronidase at 1 mM concentr...
Source: ChEMBL
Target: Beta-glucuronidase
External Id: CHEMBL648355

Name: Interaction percent with DPPH after 20 minutes was determined at 0.1 mM concentration
Source: ChEMBL
Target: N/A
External Id: CHEMBL847000

Name: Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM
Source: ChEMBL
Target: N/A
External Id: CHEMBL1913206

Name: Interaction percent with DPPH after 60 minutes was determined at 0.2 mM concentration
Source: ChEMBL
Target: N/A
External Id: CHEMBL845755

Total 34, Current Page 1 of 4

7-methyl-coumarin

7-Methyl-2H-1-benzopyran-2-one

7-Methyl-2H-chromen-2-one

2H-1-Benzopyran-2-one,7-methyl

7-Methylcoumarin

EINECS 219-499-3

7-Methyl-cumarin

COUMARIN,7-METHYL

7-Methylchromen-2-one

7-methyl-chromen-2-one

MFCD00006880

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China
Product Name: 7-Methylcoumarin
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
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