7-Methylcoumarin

Modify Date: 2024-01-02 19:49:30

7-Methylcoumarin structure	Common Name	7-Methylcoumarin
	CAS Number	2445-83-2	Molecular Weight	160.17
	Density	1.2±0.1 g/cm3	Boiling Point	313.1±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈O₂	Melting Point	128-130 °C(lit.)
	MSDS	Chinese USA	Flash Point	125.9±19.5 °C

Use of 7-Methylcoumarin

7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect[1].

Name	7-methylchromen-2-one
Synonym	More Synonyms

Description	7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Sancheti S, et, al. Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36(1):42-7.

Density	1.2±0.1 g/cm3
Boiling Point	313.1±0.0 °C at 760 mmHg
Melting Point	128-130 °C(lit.)
Molecular Formula	C₁₀H₈O₂
Molecular Weight	160.17
Flash Point	125.9±19.5 °C
Exact Mass	160.052429
PSA	30.21000
LogP	1.85
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.583

7-Methylcoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN7792100

CHEMICAL NAME :: Coumarin, 7-methyl-

CAS REGISTRY NUMBER :: 2445-83-2

BEILSTEIN REFERENCE NO. :: 0122625

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H8-O2

MOLECULAR WEIGHT :: 160.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 258 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,186,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7980 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	23/24/25
Safety Phrases	S1-S13-S45
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	GN7792100
HS Code	2932209090

Precursor 10
CAS#:698-27-1 2-Hydroxy-4-met... CAS#:927-80-0 Ethoxyethyne CAS#:617-48-1 (±)-Malic Acid CAS#:108-39-4 m-Cresol
CAS#:292638-85-8 acrylic acid me... CAS#:141-32-2 butyl acrylate CAS#:591-24-2 UNII:255L4HTY2B CAS#:115560-73-1 3-hydroxy-3-(2-...
CAS#:57234-27-2 1-(methoxymetho... CAS#:108-24-7 Ethanoic anhydride
DownStream 7
CAS#:50-85-1 2-Hydroxy-4-met... CAS#:50779-65-2 6-Methyl-benzof... CAS#:20921-01-1 7-methylchroman... CAS#:17397-70-5 Coumarin-7-carb...
CAS#:53666-75-4 7-methyl-6-nitr... CAS#:848352-37-4 7-methyl-3,6-di... CAS#:53878-12-9 7-(bromomethyl)...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001)

A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main compone...

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes.

Xenobiotica 46 , 14-24, (2016)

1. Information about the metabolism of compounds is essential in drug discovery and development, risk assessment of chemicals and further development of predictive methods. 2. In vitro and in silico m...

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 7-Methylcoumarin
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: 7-Methylcoumarin
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2H-1-Benzopyran-2-one,7-methyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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