61618-27-7
61618-27-7 structure
- Name: Amfenac Sodium Monohydrate
- Chemical Name: amfenac sodium hydrate
- CAS Number: 61618-27-7
- Molecular Formula: C15H14NNaO4
- Molecular Weight: 295.266
- Catalog: Biochemical Inhibitor Neuronal Signaling COX inhibitor
- Create Date: 2018-09-22 17:05:16
- Modify Date: 2026-07-03 15:53:35
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Amfenac Sodium Hydrate is a COX-2 inhibitor.
| Name | amfenac sodium hydrate |
|---|---|
| Synonyms |
Benzeneacetic acid, 2-amino-3-benzoyl-, monosodium salt,monohydrate
Sodium 2-(2-amino-3-benzoylphenyl)acetate hydrate Amfenac Sodium Salt Hydrate AHR-5850D Sodium 2-(2-amino-3-benzoylphenyl) Amfenac-d5 Sodium Salt AMfenac sodiuM(Fenazox) Amfenac Sodium SaltQ: What is Amfenac Sodium Salt Q: What is the CAS Number of Amfenac Sodium Salt Q: What is the storage condition of Amfenac Sodium Salt Amfenac sodium hydrate, >= 2-Amino-3-benzoylbenzeneacetic acid, monosodium salt, monohydrate 2-Amino-3-benzoylbenzeneacetic Acid SodiuM Salt Hydrate Fenazox //BP 2-Amino-3-benzoylbenzeneacetic acid,monosodium salt,monohydrate AMFENAC SODIUM Benzeneacetic acid, 2-amino-3-benzoyl-, sodium salt, hydrate (1:1:1) Fenazox Sodium (2-amino-3-benzoylphenyl)acetate hydrate (1:1:1) Benzeneacetic acid, 2-amino-3-benzoyl-, sodium salt, monohydrate Amfenac Sodium Hydrate, 10 mM in DMSO 2-Amino-3-benzoylbenzeneacetic acid sodium salt hydrate Amfenac sodium hydrate Amfenac Sodium Salt Amfenac Amfenac Sodium Hydrate Sodium aminophenate Amfenac sodium salt hydrate AMFENAC SODIUM MONOHYDRATE acetate hydrate Amfenac sodium salt monohydrate sodium,2-(2-amino-3-benzoylphenyl)acetate,hydrate Amfenac sodium monohydrate |
| Description | Amfenac Sodium Hydrate is a COX-2 inhibitor. |
|---|---|
| Related Catalog | |
| Target |
COX-2 |
| In Vitro | Cells transfected to express COX-2 have a higher proliferation rate than those do not. The addition of Amfenac Sodium Hydrate significantly decreases the proliferation rate of all cell lines. Nitric oxide production by macrophages is inhibited by the addition of melanoma conditioned medium, the addition of Amfenac Sodium Hydrate partially overcomes this inhibition[1]. Results show that Amfenac Sodium Hydrate inhibits the release of B-glucuronidase: 5×10-4 M Amfenac Sodium Hydrate inhibits the release of the enzyme 35.3 and 16.3% in the presence of 10-8, and 10-7 M FMLP, respectively. Addition of 10-4 M Amfenac Sodium Hydrate causes 28.3% inhibition of aggregation of polgmorphonuclear leukocgtes (PMNs) during incubation for 16 min with 10-8 M FMLP[2]. |
| Cell Assay | Human uveal melanoma cell lines are transfected to constitutively express COX-2 and the proliferative rate of these cells using two different methods, with and without the addition of Amfenac Sodium Hydrate, is measured. Nitric oxide production by macrophages is measured after exposure to melanoma-conditioned medium from both groups of cells as well as with and without Amfenac Sodium Hydrate[1]. |
| References |
| Boiling Point | 520ºC at 760 mmHg |
|---|---|
| Melting Point | 242-244ºC |
| Molecular Formula | C15H14NNaO4 |
| Molecular Weight | 295.266 |
| Flash Point | 268.3ºC |
| Exact Mass | 295.082062 |
| PSA | 92.45000 |
| LogP | 1.30910 |
| Storage condition | Refrigerator |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2922509090 |
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |