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56365-38-9

56365-38-9 structure
56365-38-9 structure
  • Name: Capillarisin
  • Chemical Name: 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one
  • CAS Number: 56365-38-9
  • Molecular Formula: C16H12O7
  • Molecular Weight: 316.262
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-05-01 08:00:00
  • Modify Date: 2025-08-25 04:26:06
  • Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3].
Name 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one
Synonyms 5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one
Capillarisin
X1106
Capillarisine
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-
2-(p-Hydroxyphenoxy)-6-methoxy-5,7-dihydroxychromone
Description Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3].
Related Catalog
In Vitro Capillarisin (0~40 μM; 24 hours; SH-SY5Y cells) does not produce any significant changes on the viability of SH-SY5Y cells[3]. .Capillarisin (40 μM; 24 hours; SH-SY5Y cells) induces PI3K/PKB pathway inactivation, which inhibiting apoptosis in bupivacaine-challenged SH-SY5Y cells is overturned by LY294002 treatment and counteracts bupivacaine-induced injury via activating the PI3K/PKB pathway[3]. .Capillarisin antagonizes bupivacaine-induced oxidative stress via activating the PI3K/PKB pathway in SH-SY5Y cells. Capillarisin inhibits bupivacaine-induced mitochondrial injury and endoplasmic reticulum stress via activating PI3K/PKB pathway[3]. Cell Viability Assay[3] Cell Line: SH-SY5Y cells Concentration: 0~40 μM Incubation Time: 24 hours Result: Did not produce any significant changes on the viability of SH-SY5Y cells. Western Blot Analysis[3] Cell Line: SH-SY5Y cells Concentration: 40 μM Incubation Time: 24 hours Result: Induced PI3K/PKB pathway inactivation in SH-SY5Y cells. Apoptosis Analysis[3] Cell Line: SH-SY5Y cells Concentration: 40 μM Incubation Time: 24 hours Result: Induced inhibition of apoptosis in bupivacaine-challenged SH-SY5Y cells was overturned by LY294002 treatment.
In Vivo Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4]. Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4]. Animal Model: ICR mice[4] Dosage: 20 and 80 mg/kg Administration: I.p.; 1 hour Result: Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2).
References

[1]. Peng G, et al. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pak J Pharm Sci. 2020;33(4(Supplementary)):1907-1915.

[2]. Komiya T, et al. Capillarisin, a Constituent from Artemisiae Capillaris Herba. Chemical and Pharmaceutical Bulletin, 1975

[3]. Zhao T, Wang Q. Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. Life Sci. 2020;259:118279.

[4]. Khan S, et al. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. J Ethnopharmacol. 2014;152(3):478-486.
Density 1.6±0.1 g/cm3
Boiling Point 582.6±50.0 °C at 760 mmHg
Molecular Formula C16H12O7
Molecular Weight 316.262
Flash Point 221.2±23.6 °C
Exact Mass 316.058289
PSA 109.36000
LogP 2.28
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.695
Hazard Codes Xi
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