Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Imirestat
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Purity: 98.0%
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89391-50-4

89391-50-4 structure

89391-50-4 structure

Name: IMIRESTAT
Chemical Name: 2,7-difluorospiro[fluorene-9,5'-imidazolidine]-2',4'-dione
CAS Number: 89391-50-4
Molecular Formula: C₁₅H₈F₂N₂O₂
Molecular Weight: 286.23300
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
Create Date: 2018-07-08 19:13:40
Modify Date: 2024-01-04 18:33:40
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

Name	2,7-difluorospiro[fluorene-9,5'-imidazolidine]-2',4'-dione
Synonyms	Imirestatum [INN-Latin] Alcon 1576 2,7-Difluorospiro(fluorene-9,4'-imidazolidine)-2',5'-dione 2,7-di-fluoro-spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione Imirestat spiro-[2,7-difluorofluoren-9,4'-imidazolidine]-2',5'-dione Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione,2,7-difluoro [14C]-Imirestat Spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione HOE 843

Description	Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Metabolic Disease
In Vivo	Imirestat (1 mg/kg) improves nerve conduction velocity but is without effect upon the resistance to hypoxic conduction blockade or the deficit in insulin-stimulated oubain-sensitive ATPase activity[1].
References	[1]. Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401.

Density	1.58g/cm3
Molecular Formula	C₁₅H₈F₂N₂O₂
Molecular Weight	286.23300
Exact Mass	286.05500
PSA	58.20000
LogP	2.68580
Index of Refraction	1.692
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1307300

CHEMICAL NAME :: Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2,7-difluoro-

CAS REGISTRY NUMBER :: 89391-50-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H8-F2-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg/14D-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 700 mg/kg/14D-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997

24313-53-9 structure

24313-53-9

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89391-50-4 structure

89391-50-4

Literature: Alcon Laboratories, Inc. Patent: US4436745 A1, 1984 ; Title/Abstract Full Text Show Details Alcon Laboratories, Inc. Patent: US4540700 A1, 1985 ;

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