Shanghai Nianxing Industrial Co., Ltd
China
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GL Biochem (Shanghai) Ltd.
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Nanjing Peptide Biotech Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Taiwan Oyi peptide Co. Ltd
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108433-99-4

108433-99-4 structure

108433-99-4 structure

Name: Magainin 1
Chemical Name: magainin i
CAS Number: 108433-99-4
Molecular Formula: C₁₁₂H₁₇₇N₂₉O₂₈S
Molecular Weight: 2409.85000
Catalog: Peptides
Create Date: 2018-06-19 16:49:46
Modify Date: 2024-01-02 19:37:42
Magainin 1 is an antimicrobial peptide discovered in the skin of Xenopus laevis.

Name	magainin i
Synonyms	GLY-ILE-GLY-LYS-PHE-LEU-HIS-SER-ALA-GLY-LYS-PHE-GLY-LYS-ALA-PHE-VAL-GLY-GLU-ILE-MET-LYS-SER Gly-L-Ile-Gly-L-Lys-L-Phe-L-Leu-L-His-L-Ser-L-Ala-Gly-L-Lys-L-Phe-Gly-L-Lys-L-Ala-L-Phe-L-Val-Gly-L-Glu-L-Ile-L-Met-L-Lys-L-Ser-OH MAGAININ 1 (FROG,XENOPUS LAEVIS) H-GLY-ILE-GLY-LYS-PHE-LEU-HIS-SER-ALA-GLY-LYS-PHE-GLY-LYS-ALA-PHE-VAL-GLY-GLU-ILE-MET-LYS-SER-OH GIGKFLHSAGKFGKAFVGEIMKS Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-OH MAGAININ 1

Description	Magainin 1 is an antimicrobial peptide discovered in the skin of Xenopus laevis.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Anti-infection >> Fungal Peptides Research Areas >> Infection Natural Products >> Others
In Vitro	Magainin 1 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes[1]. Magainin 1 and 2 have a similar amino-acid sequence. Magainin 2 has higher antimicrobial activity than magainin 1[2]. Magainin 1 interacts with acidic lipids through electrostatic interactions followed by hydrophobic interactions to form an amphiphilic helix, inducing the leakage. Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. The peptide binds to bovine brain phosphatidylserine sonicated vesicles according to the Langmuir isotherm with a binding constant of 3.8×105 M-1 and a binding-site number of 0.10 per lipid molecule[3]. Magainin 2 displays antibiotic activity against numerous Gram-negative and Gram-positive bacteria. A similar spectrum of activity is seen on assay of magainin 1[4].
References	[1]. Matsuzaki K, et al. Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim Biophys Acta. 1998 Nov 10;1376(3):391-400. [2]. Watanabe H, et al. Channel Current Analysis for Pore-forming Properties of an Antimicrobial Peptide, Magainin 1, Using the Droplet Contact Method. Anal Sci. 2016;32(1):57-60. [3]. Matsuzaki K, et al. Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles. Biochim Biophys Acta. 1989 May 19;981(1):130-4. [4]. Zasloff M, et al. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.

Molecular Formula	C₁₁₂H₁₇₇N₂₉O₂₈S
Molecular Weight	2409.85000
Exact Mass	2408.30000
PSA	939.34000
LogP	4.96870
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T+
RIDADR	NONH for all modes of transport
WGK Germany	3