154-69-8
154-69-8 structure
- Name: Tripelennamine (hydrochloride)
- Chemical Name: tripelennamine hydrochloride
- CAS Number: 154-69-8
- Molecular Formula: C16H22ClN3
- Molecular Weight: 291.81900
- Catalog: API Antiallergic Antihistamine
- Create Date: 2018-07-07 16:54:30
- Modify Date: 2026-07-01 10:38:40
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Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.IC50 Value:Target: Histamine H1 receptorTripelennamine can be used in the treatment of asthma, hay fever, rhinitus and urticaria.in vitro: Arterial and mixed venous blood-gas and pH measurements were made at rest before and after saline or drug administration and during incremental exercise leading to maximal exertion at 14 m/s on 3.5% uphill grade for 120 s. Galloping at this workload elicited maximal heart rate and induced exercise-induced pulmonary hemorrhage in all horses in both treatments, thereby indicating that capillary stress failure-related pulmonary injury had occurred [1].in vivo: The data obtained (median and range in brackets) in camels and horses, respectively, were as follows: the terminal elimination half-lives were 2.39 (1.91-6.54) and 2.08 (1.31-5.65) h, total body clearances were 0.97 (0.82-1.42) and 0.84 (0.64-1.17)L/h/kg. The volumes of distribution at steady state were 2.87 (1.59-6.67) and 1.69 (1.18-3.50) L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model were 1.75 (0.68-2.27) and 1.06 (0.91-2.20) L/kg [2]. After intramuscular administration of 50 or 100 mg tripelennamine, mean plasma concentrations at 30 minutes were 105 and 194 ng/ml, respectively, and mean plasma t1/2 values were 2.9 and 4.4 hours, respectively [3].
| Name | tripelennamine hydrochloride |
|---|---|
| Synonyms |
N1,N1-Dimethyl-N2-(phenylmethyl)-N2-(2-pyridinyl)-1,2-ethanediamine hydrochloride
PYRIBENZAMINE HCL EINECS 205-833-5 2-ethanediamine,n,n-dimethyl-n’-(phenylmethyl)-n’-2-pyridinyl-monohydroc ReCovr TRIPELENNAMINE HYDROCHLORIDE //BP Tripyridamole hydrochloride N1-Benzyl-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine hydrochloride N-Benzyl-N',N'-diMethyl-N-2-pyridylethylen tripelennaminemonohydrochloride 1,2-Ethanediamine,N1,N1-dimethyl-N2-(phenylmethyl)-N-pyridinyl-, hydrochloride (1:1) tri-tumine n,n-dimethyl-n’-(2-pyridyl)-n’-benzylethylenediaminehydrochloride pyribenzaminemonohydrochloride Ahistamin Tripelennamine Hydrochloride Standd Tripelennanmine Hydrochloride Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)-, hydrochloride 2-[BENZYL(2-DIMETHYLAMINOETHYL)AMINO]PYRIDINE HYDROCHLORIDE stanzamine Antiallergicum medivet 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride TripelennaMine HCI dehistinmonohydrochloride Tripelennamine,Inhibitor,inhibit,antihistaminic,Tripelennamine hydrochloride,Histamine Rector,rhinitis,allergic response,conjunctivitis,Endogenous Metabolite Tripelennamine Hydrochloride n-benzyl-n-dimethylaminoethylalpha-aminopyridinehydrochloride 2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride Avanafil Impurity dehistin TRIPELENNAMINE HCL piristin N(Sup 1)-.alpha.-pyridyl-N(sup 1)-benzyl-N,N-dimethyl ethylenediamine monohydrochloride PYRIDINE,2-(BENZYL(2-(DIMETHYLAMINO)ETHYL)AMINO)-,MONOHYDROCHLORIDE tripelenaminehydrochloride N-Benzyl-N',N'-dimethyl-N-pyridin-2-yl-ethane-1,2-diamine HYDROCHLORIDE Chloropyramine Impurity 1 HCl (Tripelennamine HCl, Pyribenzamine HCl) 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinhydrochloride N-benzyl-N-(2-(dimethylamino)ethyl)pyridin-2-amine hydrochloride n-benzyl-n’,n’-dimethyl-n-(2-pyridyl)-ethylenediaminhydrochloride Azon pyrabenzamine 2-(benzyl[2-dimethylaminoethyl]amino)pyridine 2-(Benzyl[2-dimethylaminoethyl]amino)pyridine, N-Benzyl-Nμ,Nμ-dimethyl-N-(2-pyridyl)ethylenediamine hydrochloride pyrinamine TRIPELENNAMINEHYDROCHLORIDE n-benzyl-n-alpha-pyridyl-n’,n’-dimethyl-aethylendiamin-hydrochlorid N,N-dimethyl-N'-(phenylmethyl)-N'-(2-pyridinyl)ethane-1,2-diamine hydrochloride TRIPELENNAMINE HYDROCHLORIDE TABLETS Chloropyramine Impurity 1 HCl Tripelennamine hydrochloride in methanol Tripelenamin*HCl 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride TRIPELENAMINEHCL Azaron pyribenzaminehydrochloride TIANFU -8 TRIPELENNAMINE HYDROCHLORIDE n-benzyl-n’,n’-dimethyl-n-2-pyridyl-ethylenediaminehydrochloride n(sup1)-alpha-pyridyl-n(sup1)-benzyl-n,n-dimethylethylenediaminemonohydro BMS-986165 (Deucravacitinib) second-generation tripelennamine HCl |
| Description | Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.IC50 Value:Target: Histamine H1 receptorTripelennamine can be used in the treatment of asthma, hay fever, rhinitus and urticaria.in vitro: Arterial and mixed venous blood-gas and pH measurements were made at rest before and after saline or drug administration and during incremental exercise leading to maximal exertion at 14 m/s on 3.5% uphill grade for 120 s. Galloping at this workload elicited maximal heart rate and induced exercise-induced pulmonary hemorrhage in all horses in both treatments, thereby indicating that capillary stress failure-related pulmonary injury had occurred [1].in vivo: The data obtained (median and range in brackets) in camels and horses, respectively, were as follows: the terminal elimination half-lives were 2.39 (1.91-6.54) and 2.08 (1.31-5.65) h, total body clearances were 0.97 (0.82-1.42) and 0.84 (0.64-1.17)L/h/kg. The volumes of distribution at steady state were 2.87 (1.59-6.67) and 1.69 (1.18-3.50) L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model were 1.75 (0.68-2.27) and 1.06 (0.91-2.20) L/kg [2]. After intramuscular administration of 50 or 100 mg tripelennamine, mean plasma concentrations at 30 minutes were 105 and 194 ng/ml, respectively, and mean plasma t1/2 values were 2.9 and 4.4 hours, respectively [3]. |
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| Related Catalog | |
| References |
| Density | 1.20 |
|---|---|
| Boiling Point | 387.8ºC at 760 mmHg |
| Melting Point | 192-193ºC |
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | 291.81900 |
| Flash Point | 188.3ºC |
| Exact Mass | 291.15000 |
| PSA | 19.37000 |
| LogP | 3.45180 |
| Vapour Pressure | 3.21E-06mmHg at 25°C |
| Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | US3150000 |
| HS Code | 2933399090 |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |