Tripelennamine (hydrochloride)
Tripelennamine (hydrochloride) structure
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Common Name | Tripelennamine (hydrochloride) | ||
|---|---|---|---|---|
| CAS Number | 154-69-8 | Molecular Weight | 291.81900 | |
| Density | 1.20 | Boiling Point | 387.8ºC at 760 mmHg | |
| Molecular Formula | C16H22ClN3 | Melting Point | 192-193ºC | |
| MSDS | Chinese USA | Flash Point | 188.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Tripelennamine (hydrochloride)Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.IC50 Value:Target: Histamine H1 receptorTripelennamine can be used in the treatment of asthma, hay fever, rhinitus and urticaria.in vitro: Arterial and mixed venous blood-gas and pH measurements were made at rest before and after saline or drug administration and during incremental exercise leading to maximal exertion at 14 m/s on 3.5% uphill grade for 120 s. Galloping at this workload elicited maximal heart rate and induced exercise-induced pulmonary hemorrhage in all horses in both treatments, thereby indicating that capillary stress failure-related pulmonary injury had occurred [1].in vivo: The data obtained (median and range in brackets) in camels and horses, respectively, were as follows: the terminal elimination half-lives were 2.39 (1.91-6.54) and 2.08 (1.31-5.65) h, total body clearances were 0.97 (0.82-1.42) and 0.84 (0.64-1.17)L/h/kg. The volumes of distribution at steady state were 2.87 (1.59-6.67) and 1.69 (1.18-3.50) L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model were 1.75 (0.68-2.27) and 1.06 (0.91-2.20) L/kg [2]. After intramuscular administration of 50 or 100 mg tripelennamine, mean plasma concentrations at 30 minutes were 105 and 194 ng/ml, respectively, and mean plasma t1/2 values were 2.9 and 4.4 hours, respectively [3]. |
Summary: Tripelennamine hydrochloride, also known as tripelennamine (hydrochloride), is an H1 receptor antagonist with CAS number 154-69-8 and molecular formula C16H22ClN3, molecular weight 291.81900. It is a white solid with a melting point of 192-193ºC. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | tripelennamine hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.IC50 Value:Target: Histamine H1 receptorTripelennamine can be used in the treatment of asthma, hay fever, rhinitus and urticaria.in vitro: Arterial and mixed venous blood-gas and pH measurements were made at rest before and after saline or drug administration and during incremental exercise leading to maximal exertion at 14 m/s on 3.5% uphill grade for 120 s. Galloping at this workload elicited maximal heart rate and induced exercise-induced pulmonary hemorrhage in all horses in both treatments, thereby indicating that capillary stress failure-related pulmonary injury had occurred [1].in vivo: The data obtained (median and range in brackets) in camels and horses, respectively, were as follows: the terminal elimination half-lives were 2.39 (1.91-6.54) and 2.08 (1.31-5.65) h, total body clearances were 0.97 (0.82-1.42) and 0.84 (0.64-1.17)L/h/kg. The volumes of distribution at steady state were 2.87 (1.59-6.67) and 1.69 (1.18-3.50) L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model were 1.75 (0.68-2.27) and 1.06 (0.91-2.20) L/kg [2]. After intramuscular administration of 50 or 100 mg tripelennamine, mean plasma concentrations at 30 minutes were 105 and 194 ng/ml, respectively, and mean plasma t1/2 values were 2.9 and 4.4 hours, respectively [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.20 |
|---|---|
| Boiling Point | 387.8ºC at 760 mmHg |
| Melting Point | 192-193ºC |
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | 291.81900 |
| Flash Point | 188.3ºC |
| Exact Mass | 291.15000 |
| PSA | 19.37000 |
| LogP | 3.45180 |
| Vapour Pressure | 3.21E-06mmHg at 25°C |
| InChIKey | FSSICIQKZGUEAE-UHFFFAOYSA-N |
| SMILES | CN(C)CCN(Cc1ccccc1)c1ccccn1.Cl |
| Storage condition | Refrigerator |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | US3150000 |
| HS Code | 2933399090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Ahistamin |
| Tripelennamine (hydrochloride) |
| EINECS 205-833-5 |
| ReCovr |
| dehistin |
| pyrabenzamine |
| pyrinamine |
| piristin |
| stanzamine |
| Tripelenamin*HCl |
| TRIPELENAMINEHCL |
| Azaron |
| tri-tumine |
| tripelennamine HCl |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of tripelennamine hydrochloride? |
| A: Polar surface area (PSA) of tripelennamine hydrochloride is 19.37000. |
| Q: What English synonyms does tripelennamine hydrochloride have? |
| A: English synonyms of tripelennamine hydrochloride: Ahistamin, Tripelennamine (hydrochloride), EINECS 205-833-5, ReCovr, dehistin, pyrabenzamine, pyrinamine, piristin, stanzamine, Tripelenamin*HCl, TRIPELENAMINEHCL, Azaron, tri-tumine, tripelennamine HCl. |
| Q: What is the safety information for tripelennamine hydrochloride? |
| A: Safety information for tripelennamine hydrochloride: 26-36. |
| Q: What is the molecular weight of tripelennamine hydrochloride? |
| A: Molecular weight of tripelennamine hydrochloride is 291.81900. |
| Q: What is the CAS number of tripelennamine hydrochloride? |
| A: CAS number of tripelennamine hydrochloride is 154-69-8. |
| Q: What is the boiling point of tripelennamine hydrochloride? |
| A: Boiling point of tripelennamine hydrochloride is 387.8ºC at 760 mmHg. |
| Q: What is the LogP of tripelennamine hydrochloride? |
| A: LogP of tripelennamine hydrochloride is 3.45180. |
| Q: What are the storage conditions for tripelennamine hydrochloride? |
| A: Storage conditions for tripelennamine hydrochloride: Refrigerator. |
| Q: What is the melting point of tripelennamine hydrochloride? |
| A: Melting point of tripelennamine hydrochloride is 192-193ºC. |
| Q: What is the InChIKey of tripelennamine hydrochloride? |
| A: InChIKey of tripelennamine hydrochloride is FSSICIQKZGUEAE-UHFFFAOYSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |