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1963-36-6

1963-36-6 structure
1963-36-6 structure
  • Name: 4-Methoxycinnamaldehyde
  • Chemical Name: p-Methoxycinnamic aldehyde
  • CAS Number: 1963-36-6
  • Molecular Formula: C10H10O2
  • Molecular Weight: 162.185
  • Catalog: Chemical reagent Organic reagent Aromatic hydrocarbon
  • Create Date: 2018-06-11 14:31:26
  • Modify Date: 2024-01-03 19:11:11
  • 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].

Name p-Methoxycinnamic aldehyde
Synonyms 3-(4-Methoxyphenyl)-2-propenal
3-p-methoxyphenyl-2-propenal
p-Methoxycinnamaldehyde
4-Methoxycinnamaldehyde
2-Propenal, 3-(4-methoxyphenyl)-
4-Methoxybenzeneacrolein
Einecs 217-807-0
4-Methoxyciamaldehyde
Fema no. 3567
3-(4-Methoxyphenyl)acrylaldehyde
VH1U1R DO1
trans-4-Methoxycinnamaldehyde
para-methoxycinnamaldehyde
Methoxycinnamaldehyde,p
4-Methoxybenzenepropenal
Description 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].
Related Catalog
References

[1]. Kuo Chih Wang, et al. 4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line. Phytomedicine. 2009 Sep;16(9):882-6.

Density 1.1±0.1 g/cm3
Boiling Point 308.7±17.0 °C at 760 mmHg
Melting Point 55-60ºC(lit.)
Molecular Formula C10H10O2
Molecular Weight 162.185
Flash Point 146.5±14.5 °C
Exact Mass 162.068085
PSA 26.30000
LogP 2.07
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.559

Section I.Chemical Product and Company Identification
Chemical Name 4-Methoxycinnamaldehyde
Portland OR
Synonym3-(4-methoxyphenyl)acrylaldehyde
Chemical FormulaCH3OC6H4CH:CHCHO
CAS Number1963-36-6

Section II.Composition and Information on Ingredients
Chemical NameCAS Number Percent (%)TLV/PELToxicology Data
4-Methoxycinnamaldehyde1963-36-6Min. 97.0 Not available.Not available.
(GC)

Section III. Hazards Identification
Acute Health EffectsIrritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,
or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when
handling this compound.
CARCINOGENIC EFFECTS : Not available.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available.
There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is
not known to aggravate existing medical conditions.

Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. DO NOT use an eye ointment. Flush eyes with running water for a minimum
of 15 minutes, occasionally lifting the upper and lower eyelids. Seek medical attention. Treat symptomatically and
supportively.
Skin ContactIf the chemical gets spilled on a clothed portion of the body, remove the contaminated clothes as quickly as possible,
protecting your own hands and body. Place the victim under a deluge shower. If the chemical touches the victim's
exposed skin, such as the hands: Gently and thoroughly wash the contaminated skin with running water and non-abrasive
soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. Seek
medical attention. Treat symptomatically and supportively. Wash any contaminated clothing before reusing.
InhalationIf the victim is not breathing, perform artificial respiration. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, oxygen can be administered. Seek medical attention. Treat symptomatically and supportively.
Remove dentures if any. Have conscious person drink several glasses of water or milk. INDUCE VOMITING by sticking
Ingestion
finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. NEVER give an unconscious
person anything to ingest. Seek medical attention. Treat symptomatically and supportively.

Section V. Fire and Explosion Data
Not available.
FlammabilityCombustible.Auto-Ignition
Flammable Limits
Flash PointsNot available.
Not available.
Combustion ProductsThese products are carbon oxides (CO, CO 2).
Fire Hazards
No specific information is available regarding the flammability of this compound in the presence of various materials.
Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
No additional information is available regarding the risks of explosion.
Fire Fighting Media
SMALL FIRE: Use DRY chemicals, CO 2, water spray or foam.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Continued on Next Page
4-Methoxycinnamaldehyde

Section VI.Accidental Release Measures
Spill CleanupIn case of a spill and/or a leak, always shut off any sources of ignition, ventilate the area, and exercise caution. Use a
Instructionsshovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
disposal.

Section VII. Handling and Storage
Handling and StorageIRRITANT. Keep away from heat and sources of ignition. Mechanical exhaust required. When not in use, tightly seal the
container and store in a dry, cool place. Avoid excessive heat and light. DO NOT ingest. DO NOT breathe dust. In case
Information
of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the
container or the label. Treat symptomatically and supportively. Avoid contact with skin and eyes.
Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSplash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling
this product.
Exposure LimitsNot available.

Section IX. Physical and Chemical Properties
Solubility
Physical state @ 20°CSolid. (Powder.)Not available.
Not available.
Specific Gravity
Molecular Weight162.19Partition CoefficientNot available.
Boiling PointNot available.Vapor PressureNot available.
Melting Point58°C (136.4°F)Vapor DensityNot available.
Not available.VolatilityNot available.
Refractive Index
Critical TemperatureOdorNot available.
------------
ViscosityNot available.TasteNot available.

Section X.Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability
Air and light sensitive.
Incompatibilities
Highly reactive with oxidizing agents.

Section XI. Toxicological Information
RTECS NumberNot available.
Routes of ExposureIngestion. Inhalation. Eye contact. Skin contact.
Not available.
Toxicity Data
No additional remark.
Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available.
There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is not
known to aggravate existing medical conditions.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
Acute Toxic Effects
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,
or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when
handling this compound.
Continued on Next Page
4-Methoxycinnamaldehyde

Section XII.Ecological Information
EcotoxicityNot available.
Environmental FateNot available.

Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with
Waste Disposal
a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state, and local regulations when disposing of this substance.

Section XIV. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
PIN NumberNot available.
Proper Shipping Name
Not available.
Packing Group (PG)Not available.
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is ON the Toxic Substances Control Act (TSCA) list.
(EPA)
WHMIS Classification
WHMIS CLASS D-2B: Material causing other toxic effects (TOXIC).
(Canada)
EINECS Number (EEC) Not available.
EEC Risk StatementsR36/38- Irritating to eyes and skin.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
WGK Germany 3
HS Code 2912499000
HS Code 2912499000
Summary 2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%